Sleep matters: Sleep functioning and course of illness in bipolar disorder
Sleep matters: Sleep functioning and course of illness in bipolar disorder
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DOI：
10.1016/j.jad.2011.05.016
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发表时间：
2011-11-01
影响因子：
6.6
通讯作者：
Ketter, Terence A.
中科院分区：
文献类型：
--
作者：
Gruber, June;Miklowitz, David J.;Ketter, Terence A.
背景资料：很少有研究前瞻性地研究睡眠与双相情感障碍症状和功能的关系。方法：本研究在DSM-IV双相情感障碍患者队列中检查了总睡眠时间（TST）和睡眠变异性（SV）与症状严重程度和功能之间的并行和前瞻性相关性（N = 468）参与美国国家精神卫生研究所双相情感障碍系统治疗增强计划（STEP-BD）的患者，所有患者在研究入组时均已康复。研究入组时的并发相关性表明，较短的TST与躁狂症严重程度增加相关，较大的SV与躁狂症和抑郁症严重程度增加相关。采用混合效应回归模型对196例有随访数据的患者进行前瞻性相关性研究。与研究结果一致，较短的TST与躁狂症的严重程度增加，更大的SV与躁狂症和抑郁症的严重程度增加超过12 months.Discussion：这些研究结果强调了在双相情感疾病的过程中，睡眠模式中断的重要性。(C)2011 Elsevier B. V.保留所有权利。
Background: Few studies have prospectively examined the relationships of sleep with symptoms and functioning in bipolar disorder.Methods: The present study examined concurrent and prospective associations between total sleep time (TST) and sleep variability (SV) with symptom severity and functioning in a cohort of DSM-IV bipolar patients (N = 468) participating in the National Institute of Mental Health Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), all of whom were recovered at study entry.Results: Concurrent associations at study entry indicated that shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity. Mixed-effects regression modeling was used to examine prospective associations in the 196 patients for whom follow-up data were available. Consistent with findings at study entry, shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity over 12 months.Discussion: These findings highlight the importance of disrupted sleep patterns in the course of bipolar illness. (C) 2011 Elsevier B.V. All rights reserved.