An external aortic root device for decreasing aortic regurgitation: in vitro and in vivo animal studies.
An external aortic root device for decreasing aortic regurgitation: in vitro and in vivo animal studies.
复制标题
用于减少主动脉瓣反流的外主动脉根部装置：体外和体内动物研究。
DOI：
10.1111/j.1540-8191.1994.tb00849.x
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发表时间：
1994
影响因子：
1.6
通讯作者：
Lee,RT
中科院分区：
文献类型：
--
作者：
Reimold,SC;Aranki,SF;Caguioa,ES;Solomon,SD;Birjiniuk,V;Cohn,LH;Lee,RT
AbstractObjectives：本研究的目的是确定在急性主动脉瓣反流时，是否在主动脉根部周围放置一个装置可减少主动脉瓣反流。背景：主动脉瓣反流取决于中心主动脉压和主动脉根部及瓣叶几何形状。它可能是可能的，以减少主动脉瓣返流的严重程度，通过减少主动脉根部大小或尺寸changes.Methods：主动脉瓣返流建立在8个小牛心脏标本悬挂在一个连续流system. It。在基线和在主动脉瓣环水平放置外部主动脉装置后测量逆行和顺行主动脉血流和扩张主动脉压。在另外两个样本中，在放置外部器械之前和之后，通过光纤可视化了功能不全的主动脉瓣。通过切除一部分主动脉瓣叶，在4头活小牛中通过手术创建急性主动脉瓣返流。结果：在体外小牛标本中，放置体外装置后，主动脉瓣反流流量从46.9cc/sec下降到15.1cc/sec（下降66.0%± 21.8%）（p < 0.001）。瓣口反流面积由0.13 ± 0.04 cm 2降至0.04 ± 0.02 cm 2（p < 0.001）。器械对前向血流的减少程度较小（减少20.0%± 19.2%）（p < 0.05）。将器械放置在主动脉周围可改善瓣叶对合，并通过内窥镜可视化显著减小缺损尺寸。使用外部主动脉装置与改善主动脉瓣狭窄的严重程度在三个四小牛与手术创建的aortic reflux.Concluslons：在这些初步研究中，急性实验性aortic狭窄的严重程度降低使用外部主动脉装置，可能是由于减少主动脉瓣环尺寸的变化和改善主动脉瓣叶贴壁。需要进一步研究来确定该器械在慢性主动脉瓣返流中的有效性。（J Card Surg 1994;9：304-313）
AbstractObjectives:The purpose of this study was to determine if a device placed externally around the aortic root decreases regurgitant flow in acute aortic regurgitation.Background:Aortic regurgitant flow is dependent on central aortic pressure and the aortic root and leaflet geometry. It may be possible to decrease aortic regurgitant severity by reducing aortic root size or dimension changes.Methods:Aortic regurgitation was created in eight calf heart specimens suspended in a continuous flow system. Retrograde and antegrade aortic flow and distending aortic pressure were measured at baseline and after placement of an external aortic device at the level of the aortic annulus. In two additional specimens, the incompetent aortic valve was visualized fiberoptically before and after placement of the external device. Acute aortic regurgitation was created surgically in four live calves by excising a portion of the aortic leaflets. Antegrade and retrograde flow, left ventricular pressure, and central aortic pressure were measured at baseline, after creation of aortic regurgitation, and after placement of the external device.Results:In the in vitro calf specimens, regurgitant flow decreased from 46.9 cc/sec to 15.1 cc/sec (66.0%± 21.8% decrease) after placement of the external device (p < 0.001). The regurgitant orifice area decreased from 0.13 ± 0.04 cm2to 0.04 ± 0.02 cm2after device placement (p < 0.001). Antegrade flow was reduced to a smaller extent (20.0%± 19.2% decrease) by the device (p < 0.05). Placement of the device around the aorta resulted in improved coaptation of the leaflets with a marked reduction in defect size by endoscopic visualization. Use of the external aortic device was associated with improvement in aortic regurgitant severity in three of four calves with surgically created aortic regurgitation.Concluslons:In these preliminary studies, acute experimental aortic regurgitant severity is decreased by the use of an external aortic device, probably due to reduction in aortic annular dimension changes and improved aortic leaflet apposition. Further studies are needed to determine the effectiveness of this device in chronic aortic regurgitation. (J Card Surg 1994;9:304–313)