CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES .1. THE TRANSFORMATIONS OF METHYL-BIS(BETA-CHLORO-ETHYL)AMINE IN WATER
CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES .1. THE TRANSFORMATIONS OF METHYL-BIS(BETA-CHLORO-ETHYL)AMINE IN WATER
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DOI：
10.1021/jo01175a015
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发表时间：
1946-01-01
影响因子：
3.6
通讯作者：
BERGMANN, M
中科院分区：
文献类型：
--
作者：
GOLUMBIC, C;FRUTON, JS;BERGMANN, M
在这一系列的论文中所提出的工作是为了阐明一组新的发泡化学战剂--氮素类的化学特性的某些方面。这些物质是通式RN（CH 2CH 2Cl）2的双（三氟甲基）取代的叔胺。这一系列化合物中的一种，三（邻氯乙基）胺，首先由沃德（1）描述。氮芥在水中所经历的转化被选为第一个攻击点，因为这些反应的详细知识似乎对理解氮芥的一般化学是必不可少的。此外，还研究了氮素在水中的转化
The work to be presented in this series of papers was undertaken in order to elucidate certain aspects of thechemistry of a new group of vesicant chemical warfare agents, the nitrogen mustards. These substances are bisifl-chloro-ethyl) substituted tertiary amines of the general formula RN (CH2CH2C1) 2. One compound of this series, tris (0-chl oroethyl) amine, was first described by Ward (1).The transformations undergone by the nitrogen mustards in water were chosen as the first point of attack since a detailed knowledge of these reactions seemed essential to an understanding of the general chemistry of the nitrogen mustards. Furthermore, the transformations of the nitrogen mustards in water