Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter pylori eradication and detection of API2-MALT1 fusion
Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter pylori eradication and detection of API2-MALT1 fusion
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DOI：
10.1097/00000478-200412000-00003
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发表时间：
2004-12-01
影响因子：
5.6
通讯作者：
Nakamura, S
中科院分区：
文献类型：
--
作者：
Inagaki, H;Nakamura, T;Nakamura, S
胃MALT淋巴瘤显示出独特的特征，包括幽门螺杆菌根除和API 2-MALT 1融合的消退。我们对115例进行了分子和临床病理学研究。所有根除反应病例均无API 2-MALT 1融合。所有肿瘤均为融合阳性，H均为阴性。pylori感染者对根除无反应。因此，胃MALT淋巴瘤分为三组：根除反应和融合阴性（A组，n = 72），根除无反应和融合阴性（13组，n = 22），和根除无反应和融合阳性（C组，n = 21）。A组肿瘤临床分期低，累及浅表胃壁，C组肿瘤H值低。pylori感染率、晚期临床分期和核BCL 10表达。所有C组肿瘤均表现为低级别组织学。B组肿瘤尚未得到很好的识别，常表现为淋巴结受累、胃壁深部受累和晚期临床分期，有时大细胞成分增多。多因素判别分析显示，API 2-MALT 1融合阴性、H. pylori感染、临床分期低、浅表胃壁侵犯是预测胃癌的最重要因素。这3组分类可能有助于全面了解胃MALT淋巴瘤。
Gastric MALT lymphoma shows unique features including regression by Helicobacter pylori eradication and API2-MALT1 fusion. We performed a molecular and clinicopathologic study for 115 cases. All eradication-responsive cases were devoid of API2-MALT1 fusion. All tumors positive for the fusion and all negative for H. pylori infection were nonresponsive to the eradication. Consequently, gastric MALT lymphomas were divided into three groups: Eradication-responsive and fusion-negative (group A, n = 72), eradication-nonresponsive and fusion-negative (group 13, n = 22), and eradication-nonresponsive and fusion-positive (group C, n = 2 1). Group A tumors were characterized by low clinical stage and superficial gastric wall involvement, and group C tumors by low H. pylori infection rate, advanced clinical stage, and nuclear BCL 10 expression. All group C tumors showed exclusively low-grade histology. Group B tumors, which have not been well recognized, frequently showed nodal involvement, deep gastric wall involvement, and advanced clinical stage, and sometimes an increased large cell component. A multivariate discriminant analysis revealed that responsiveness to the eradication could be predicted accurately by negative API2-MALT1 fusion, positive H. pylori infection, low clinical stage, and superficial gastric wall invasion, the former being the most important factor for the prediction. This 3-group categorization may be helpful for a comprehensive understanding of gastric MALT lymphoma.