Commonality but Diversity in Cancer Gene Fusions
Commonality but Diversity in Cancer Gene Fusions
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DOI：
10.1016/j.cell.2009.04.034
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发表时间：
2009-05-01
期刊：
影响因子：
64.5
通讯作者：
Rabbitts, Terence H.
中科院分区：
文献类型：
--
作者：
Rabbitts, Terence H.
最近癌症中基因融合的发现概括了几十年前在白血病和肉瘤中发现的染色体异常。与造血和间充质恶性肿瘤不同，癌症基因融合的一个反复出现的特征是它们会导致异常的细胞信号传导。这可能反映了这些组织分化程序的差异。
Recent findings of gene fusions in carcinomas recapitulate the discovery of chromosomal abnormalities in leukemias and sarcomas decades ago. A recurring feature of carcinoma gene fusions, in contrast to those in hematopoietic and mesenchymal malignancies, is that they result in aberrant cell signaling. This may reflect differences in the differentiation programs of these tissues.