An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries
An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries
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DOI：
10.1017/s0012162200000839
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发表时间：
2000-07-01
影响因子：
3.8
通讯作者：
Sandor, P
中科院分区：
文献类型：
--
作者：
Freeman, RD;Fast, DG;Sandor, P
我们建立了一个多点的国际数据库，包括3500名被诊断为多发性抽动症(TS)的人，总样本的男性：女性比例为4.3：1，不同地点之间差异很大；男性过剩发生在每个地点。愤怒控制问题、睡眠困难、伴奏和自伤行为只有在患有共病的个体中才达到令人印象深刻的水平，愤怒控制问题与共病密切相关，无论地点、地区，也无论是否由神经学家或精神病学家评估，平均发病年龄为6.4岁。在所有年龄段，大约12%的TS患者没有报告的共病。据报道，最常见的共病是注意力缺陷多动障碍。男性比女性更容易患上共病障碍。发病年龄越早，出现阳性家族史的可能性就越大。了解导致这些和其他变异的因素可能有助于更好地对TS进行亚型分型。由于行为问题与共病相关，它们的存在应该表明对后者的高度怀疑，后者的治疗可能至少与平局复位一样重要，因此，当研究大样本时，所建立的数据库可以作为进一步研究的切入点，结果的普适性很重要。
We have established a multisite, international database of 3500 individuals diagnosed with Tourette syndrome (TS), The male:female ratio is 4.3:1 for the total sample, with wide variation among sites; the male excess occurs at every site. Anger control problems, sleep difficulties, coprolalia, and self-injurious behavior only reach impressive levels in individuals with comorbidity, Anger control problems are strongly correlated with comorbidity, regardless of site, region, or whether assessed by neurologists or psychiatrists,The mean age at onset of ties is 6.4 years. At all ages, about 12% of individuals with TS have no reported comorbidity. The most common reported comorbidity is attention-deficit-hyperactivity disorder. Males are more likely to have comorbid disorders than females. The earlier the age at onset, the greater the likelihood of a positive family history of ties. An understanding of the factors producing these and other variations might assist in better subtyping of TS. Because behavioral problems are associated with comorbidity, their presence should dictate a high index of suspicion of the latter, whose treatment may be at least as important as tie reduction, The established database can be used as the entry point for further research when large samples are studied and generalizability of results is important.