Treatment of heroin-dependent poly-drug abusers with contingency management and buprenorphine maintenance
Treatment of heroin-dependent poly-drug abusers with contingency management and buprenorphine maintenance
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DOI：
10.1037/1064-1297.8.2.176
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发表时间：
2000-05-01
影响因子：
2.3
通讯作者：
Schuster, CR
中科院分区：
文献类型：
--
作者：
Downey, KK;Helmus, TC;Schuster, CR
这项研究的目标是在丁丙诺啡维持者中进行为期12周的基于凭证的强化治疗(VBRT)阶段的多药戒断(可卡因+海洛因)戒断，而不是轭控制条件。可卡因和海洛因使用的基线水平是治疗结果的重要预测因素，无论治疗分配如何。总体而言，两组在治疗结果上没有显著差异。然而，在产生一个或多个不含多种药物的尿液结果的子样本中，VBRT参与者的可卡因戒断率显著增加，但海洛因和多种药物的戒断率并不显著，尽管所有结果都在预测的方向上。结果表明，对于那些实现多药戒断的人，VBRT可能会提高治疗结果。然而，改善干预措施，可能针对单一药物戒断，增加强化幅度，或两者兼而有之，可能是必要的，以促进该人群最初的多种药物戒除。
This study targeted poly-drug (cocaine plus heroin) abstinence among buprenorphine-maintained participants with a 12-week voucher-based reinforcement therapy (VBRT) phase versus a yoked control condition. Baseline levels of cocaine and heroin use were significant predictors of treatment outcome, regardless of treatment assignment. Overall, there were no significant group differences on treatment outcome. However, among the subsample that produced one or more poly-drug-free urine results, VBRT participants had significantly increased cocaine-but not heroin and poly-drug-abstinence, although all results were in the predicted direction. Results suggest that for those who achieve poly-drug abstinence, VBRT may enhance treatment outcome. However, improved interventions, perhaps targeting single-drug abstinence, increasing reinforcement magnitude, or both, may be necessary to promote initial poly-drug abstinence in this population.