Models for lipid organization in cholesterol-phospholipid bilayers including cholesterol dimer formation
Models for lipid organization in cholesterol-phospholipid bilayers including cholesterol dimer formation
复制标题
胆固醇-磷脂双层中的脂质组织模型，包括胆固醇二聚体形成
作者：
R. Martin;P. Yeagle
描述了三种新的结构模型，它们解释了在磷脂双层中胆固醇的几个摩尔浓度下观察到的物理性质的突然变化。胆固醇单体，每一个都被磷脂的非共享酰基烃链包围，可以容纳22%的胆固醇。胆固醇二聚体，每一个都被自己的非共享酰基烃链包围，可以容纳31%的胆固醇。当被共享的酰基烃链包围时，胆固醇二聚体可以容纳约47%的胆固醇。在更高的浓度下，胆固醇发生聚集，系统不稳定，胆固醇形成单独的相。
Three new structural models, which account for abrupt changes in physical properties observed at several molar concentrations of cholesterol in phospholipid bilayers, are described. Cholesterol monomers, each surrounded by its own envelope of unshared acyl hydrocarbon chains of the phospholipid, can accommodate 22% cholesterol. Cholesterol dimers, each surrounded by its own envelope of unshared acyl hydrocarbon chains, can accommodate 31% cholesterol. When surrounded by shared acyl hydrocarbon chains, cholesterol dimers can accommodate about 47% cholesterol. At greater concentrations, cholesterol aggregation occurs, the system is unstable, and cholesterol forms a separate phase.