Cytohistologic correlation rates between conventional Papanicolaou smears and ThinPrep cervical cytology: A comparison
Cytohistologic correlation rates between conventional Papanicolaou smears and ThinPrep cervical cytology: A comparison
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DOI：
10.1002/cncr.11102
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发表时间：
2003-06-25
影响因子：
3.4
通讯作者：
Schwartz, PE
中科院分区：
文献类型：
--
作者：
Chacho, MS;Mattie, ME;Schwartz, PE
背景。ThinPrep(R) Papanicolaou （Pap）测试是长期使用的传统巴氏涂片的液体替代品，于1996年获得美国食品和药物管理局的批准。目前的研究是通过细胞组织学相关性评估，比较医院常规与ThinPrep(R)子宫颈抹片检查的准确性。回顾性分析所有在我科1年内接受巴氏涂片检查（常规和ThinPrep）及相关手术病理组织处理的患者。组织诊断被分为与Bethesda系统相关的广泛的一般类别。两种Pap检查结果与组织诊断的差异采用1自由度卡方检验，a值为0.05。在研究期间解释的65,421例巴氏涂片中，1544例患者可能存在组织学相关性。在被诊断为阴性（644例常规涂片和245例ThinPrep涂片）、低级别鳞状上皮内病变（LGSIL）（116例常规涂片和114例ThinPrep涂片）和高级别鳞状上皮内病变（HGSIL）（142例常规涂片和131例ThinPrep涂片）的患者中，常规和ThinPrep涂片结果的相关率之间没有统计学差异。然而，对这段时间内发现的所有浸润性宫颈癌病例的回顾显示，与传统的巴氏涂片相比，ThinPrep在预测浸润性癌存在方面的一致性较差。基于细胞组织学相关证据，与传统的巴氏涂片相比，ThinPrep巴氏试验在检测宫颈疾病，特别是浸润性癌方面可能并不更有效。(C) 2003年美国癌症协会。
BACKGROUND. The ThinPrep(R) Papanicolaou (Pap) test, a liquid-based alternative to the long-used conventional Pap smear, received Food and Drug Administration approval in 1996. The current study is a comparison of the accuracy, as assessed by cytohistologic correlation, of conventional versus ThinPrep(R) Pap smears in a hospital setting.METHODS. A retrospective analysis of all patients who underwent Pap smears (conventional and ThinPrep) and pertinent surgical pathology tissue processed in our department over a 1-year period was undertaken. Tissue diagnoses were grouped into broad general categories to correlate with the Bethesda system. The statistical significance of differences between the two types of Pap test results compared with tissue diagnoses was assessed using a chi-square test with 1 degree of freedom and an a value of 0.05.RESULTS. Of the 65,421 Pap smears interpreted during the study period, histologic correlation was possible in 1544 patients. Of those diagnosed as negative (644 conventional and 245 ThinPrep Smears), low-grade squamous intraepithelial lesion (LGSIL) (116 conventional and 114 ThinPrep smears), and high-grade squamous intraepithelial lesions (HGSIL) (142 conventional and 131 ThinPrep smears), there was no statistically significant difference found between the correlation rates of conventional and ThinPrep Pap smear results. However, review of all cases of invasive cervical carcinoma identified during this time period showed the ThinPrep to be less consistent in predicting the presence of invasive carcinoma compared with the conventional Pap smear.CONCLUSIONS. Based on cytohistologic correlation evidence, the ThinPrep Pap test may not be more effective in detecting cervical disease, particularly invasive carcinoma, when compared with the conventional Pap smear. (C) 2003 American Cancer Society.