Quantification and bio-assay of α-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.
Quantification and bio-assay of α-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.
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DOI：
10.1080/14786419.2015.1114940
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发表时间：
2016-01-01
影响因子：
2.2
通讯作者：
Ni, Jing-man
中科院分区：
文献类型：
--
作者：
Gou, San-hu;Liu, Jie;Ni, Jing-man
本研究旨在从乌拉尔甘草菲施根中提取β-葡萄糖苷酶抑制剂。结果表明，从甘草中分离得到7个黄酮类化合物，其中化合物1-7的含量占甘草总黄酮的50%以上，化合物1和2的含量较高。β-葡萄糖苷酶抑制活性测定结果表明，化合物1-6和GTF的IC_（50）分别为31.303、30.263、23.363、19.528、10.854、26.454和21.641g/mL，比阿卡波糖的IC_（50）38.995g/mL强。这些结果表明，甘草黄酮类化合物可能成为一种有效的替代品，成为新的降血糖和抗糖尿病药物的潜在基础。[图形]。
This work aimed to investigate the -glucosidase inhibitor from the roots of Glycyrrhiza uralensis Fisch. Seven flavonoids were isolated, and the total content of compounds 1-7 were more than 50% in Glycyrrhiza total flavones (GTF), and the content of compound 1 and 2 was abundant in GTF. The results of the -glucosidase inhibitory activities indicated that compounds 1-6 and GTF respectively with the IC50 values of 31.303, 30.263, 23.363, 19.528, 10.854, 26.454 and 21.641g/mL exhibited the more potent activity than acarbose with the IC50 values of 38.995g/mL. These result suggested that Glycyrrhiza flavonoids may become a valid alternative of potential basis for new hypoglycaemic and antidiabetic agents.[GRAPHICS].