Cholangiocarcinoma
Cholangiocarcinoma
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DOI：
10.1007/978-3-319-13614-1_23
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Andrew Murphy;Derek Smith
中科院分区：
文献类型：
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作者：
Andrew Murphy;Derek Smith
胆管癌是一种少见的胆管腺癌，可分为肝内型和肝外型。肝内CCA（IH-CCA）约占所有CCA的25%，可表征为外周肿块形成或中央导管周围浸润性肿瘤。大多数患者没有已知的危险因素，但与肝硬化有很强的相关性。IH-CCA的临床表现即使在疾病的晚期也可能是非特异性的。管理结合手术切除，全身化疗，靶向放射治疗。手术不可切除的疾病是无法治愈的目前的治疗方案。建议患有不可切除或复发性疾病的患者参加临床试验并转诊至三级中心。
Cholangiocarcinoma (CCA), an uncommon biliary adenocarcinoma, can be divided into intrahepatic and extrahepatic types. Intrahepatic CCA (IH-CCA) comprises approximately 25 % of all CCAs, and can be characterized as peripheral mass-forming or central periductal infiltrating tumors. Most patients do not possess known risk factors, but a strong association with cirrhosis has been documented. The clinical presentation of IH-CCA can be nonspecific even in the late stages of the disease. Management combines surgical resection, systemic chemotherapy, and targeted radiation therapy. Surgically unresectable disease is incurable with current treatment options. Enrollment in clinical trials and referral to tertiary centers are recommended for patients with unresectable or recurrent disease.