Spatial and temporal sequence of events in cell adhesion: From molecular recognition to focal adhesion assembly
Spatial and temporal sequence of events in cell adhesion: From molecular recognition to focal adhesion assembly
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DOI：
10.1002/cbic.200400162
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发表时间：
2004-10-04
期刊：
影响因子：
3.2
通讯作者：
Addadi, L
中科院分区：
文献类型：
--
作者：
Cohen, M;Joester, D;Addadi, L
提出了一个新的概念，认为细胞周膜在调节细胞黏附的早期阶段中起着关键作用。通过多个协作性弱相互作用的快速、适应性和瞬时黏附，为细胞在承诺在特定部位黏附之前的决策过程提供了额外的调制水平。透明质酸在某些细胞中作为细胞黏附的调节剂出现，除了其手性和分子识别特性外，还通过其聚电解质特性调节结合或排斥。分析了透明质酸的生物物理性质及其超微结构与这一功能的关系。
A new concept that attributes a pivotal role to the pericellular coat in the regulation of the early stages of cell adhesion is presented. Quick, adaptable, and transient adhesion through multiple cooperative weak interactions provides the cell with an additional level of modulation in the decision-making process that precedes the commitment to adhesion at a particular site. Hyaluronan emerges as a modulator of cell adhesion in certain cells, mediating binding or repulsion through its polyelectrolyte character, in addition to its chirality and molecular-recognition properties. The biophysical properties of hyaluronan as well as its ultrastructural organization are analyzed in relation to this proposed function.