TGF-β1 polymorphism determines the progression of joint damage in rheumatoid arthritis
TGF-β1 polymorphism determines the progression of joint damage in rheumatoid arthritis
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DOI：
10.1080/03009740410010344
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发表时间：
2004-11-01
影响因子：
2.1
通讯作者：
Kang, YM
中科院分区：
文献类型：
--
作者：
Kim, SY;Han, SW;Kang, YM
目的：为了确定转化生长因子β 1方法：采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测143例RA患者和148例健康对照者的TGF-β 1基因多态性，并分析其与RA的关系结果：TGF-β 1基因多态性与RA的易感性无关，但-509C/T和869 T/C基因多态性与RA的易感性在男性人群中有关联的趋势。在-509位点，T等位基因携带者的放射学严重程度进展更快（p=0.048）。结论：我们的数据支持TGF-β 1多态性可能决定RA关节破坏进展的假设。
Objective: To determine whether transforming growth factor-beta1 (TGF-beta1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) and to analyse whether they can affect the progression of radiographic severity.Methods: A total of 143 RA patients and 148 healthy unrelated controls were tested for the TGF-beta1 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).Results: The TGF-beta1 polymorphisms were not associated with susceptibility to RA, although there was a trend that -509C/T and the 869T/C polymorphisms were associated with RA in the male population. The progression of radiographic severity, which was defined by a modified Sharp score plotted against disease duration, was significantly faster in the carrier of T allele at the -509 (p=0.048).Conclusion: Our data support the hypothesis that TGF-beta1 polymorphism may determine the progression of joint destruction in RA.