Bioactive compounds from Rumex plants
Bioactive compounds from Rumex plants
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来自酸模植物的生物活性化合物
DOI：
10.1016/j.phytol.2010.05.005
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发表时间：
2010-12-17
影响因子：
1.7
通讯作者：
Cheng, Yong-Xian
中科院分区：
文献类型：
--
作者：
Liang, Heng-Xing;Dai, Huan-Qin;Cheng, Yong-Xian
从 Rumex nepalensis 的根中分离出两种新的萘酰基葡萄糖苷，rumexneposide A (1) 和 B (2)，以及 12 种已知化合物 (3-14)。它们的结构是通过化学和光谱方法确定的。评估了化合物 1-14 以及先前从 R. nepalensis 和 Rumex hastatus (15-25) 中分离的另外 11 种化合物针对结核分枝杆菌、对氨基苯甲酸 (pAba) 途径和一组人类癌细胞系的生物活性。结果表明，化合物15对结核分枝杆菌活性最强，MIC值为2.85μM，与异烟肼相似。化合物5能够抑制pAba合成途径，其MIC值为12.6μM，与阳性对照abyssomicin C相当，代表了稀有pAba途径抑制剂的新例子。 (C) 2010 年欧洲植物化学协会。由 Elsevier B.V. 出版。保留所有权利。
Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15-25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 mu M similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 mu M, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.