Body Size, Weight Change, and Risk of Colon Cancer
Body Size, Weight Change, and Risk of Colon Cancer
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DOI：
10.1158/1055-9965.epi-10-0543
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发表时间：
2010-11-01
影响因子：
3.8
通讯作者：
Giles, Graham G.
中科院分区：
文献类型：
--
作者：
Bassett, Julie K.;Severi, Gianluca;Giles, Graham G.
背景：流行病学研究一致地报告了肥胖与男性结肠癌风险之间的正相关，但对女性来说，证据不太一致。很少有研究研究体重变化对结肠癌风险的影响。方法：采用墨尔本协作队列研究，招募的男性和女性大多在40岁到69岁之间，我们调查了18岁时和研究开始时体重与体重变化和结肠癌之间的关系。结果：在对16,188名男性和23,438名女性平均14年的随访中，我们确定了569例结肠癌。研究开始时体重和BMI与男性患结肠癌的风险呈正相关[HR，每5公斤增加1.12(95%CI，1.04-1.21)；HR，每5 kg/m(2)HR，1.39(95%CI，1.12-1.71)]，但女性没有。18岁时患结肠癌的风险与体重或BMI无关。成年体重变化与男性患结肠癌的风险呈正相关(HR，每5公斤增加1.11；95%CI，1.03-1.20)，但与女性无关(HR，1.00；95%CI，0.94-1.07)。从18岁开始体重增加20公斤的男性与体重稳定的男性相比，患结肠癌的风险更高(HR，1.47；95%CI，0.94-2.31)。结论：成年后体重增加会增加男性患结肠癌的风险。癌症流行病学生物标记物；19(11)；2978-86。(C)2010年AACR。
Background: Epidemiologic studies have consistently reported positive associations between obesity and colon cancer risk for men, but the evidence is less consistent for women. Few studies have investigated effects of weight change on colon cancer risk.Methods: Using the Melbourne Collaborative Cohort Study, which recruited men and women mostly in 40 to 69 years of age, we investigated associations between weight and body mass index (BMI) at age 18 years and at study entry and weight change since age 18 years and colon cancer. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox regression.Results: During follow-up of 16,188 men and 23,438 women for 14 years on average, we ascertained 569 incident colon cancers. Weight and BMI at study entry were positively associated with colon cancer risk for men [HR, 1.12 (95% CI, 1.04-1.21) per 5-kg increment; HR, 1.39 (95% CI, 1.12-1.71) per 5 kg/m(2)], but not women. Risk of colon cancer was not associated with weight or BMI at age 18 years. Adult weight change was positively associated with colon cancer risk for men (HR, 1.11 per 5-kg increment; 95% CI, 1.03-1.20), but not women (HR, 1.00; 95% CI, 0.94-1.07). Men who gained >= 20 kg from age 18 had an increased risk of colon cancer compared with men whose weight was stable (HR, 1.47; 95% CI, 0.94-2.31).Conclusion: Weight gain during adult life increases men's risk of colon cancer.Impact: Avoiding excessive weight gain might help reduce colon cancer risk for men. Cancer Epidemiol Biomarkers Prev; 19(11); 2978-86. (C) 2010 AACR.