Feminization of the quail by early diethylstilbestrol treatment: histoenzymological investigations on steroid dehydrogenases in the gonads.
Feminization of the quail by early diethylstilbestrol treatment: histoenzymological investigations on steroid dehydrogenases in the gonads.
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早期己烯雌酚治疗使鹌鹑雌性化：性腺中类固醇脱氢酶的组织酶学研究。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
M. Reyss
中科院分区：
文献类型：
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作者：
D. Scheib;M. Reyss
己烯雌酚（DES）对鹌鹑蛋的早期处理促进了遗传雄性性腺的短暂雌性化以及苗勒氏管的强烈刺激。左侧卵睾是由睾丸髓质和诱导的雌性型皮质并列形成的，其发育出卵泡和具有特征性的17β - 羟类固醇脱氢酶（17 beta - HSD）活性。右侧睾丸缩小但保持完整结构。在胚胎发育过程中，经处理的性腺髓质在两性中均显示出δ5 - 3β 羟类固醇脱氢酶（delta 5 - 3 beta HSD）活性受到抑制。孵化后，这种特定的酶在类固醇生成细胞中开始产生。将这些结果与使用雌二醇以及在鸡中获得的其他结果进行了比较。讨论还涉及这些雌激素对内源性能力的影响以及性腺与性别分化因素相关的特异性反应。
Early treatment of Quail eggs by DES promotes a transient feminization of the gonads in genetic males and a strong stimulation of the Müllerian ducts. The left ovotestis results from the juxtaposition of a testicular medulla and an induced female-type cortex, which develops follicles and a characteristic 17 beta-HSD activity. The right testis is reduced but keeps a consistent structure. The medulla of the treated gonads shows, in both sexes, an inhibition of delta 5-3 beta HSD activity during embryonic development. After hatching, this specific enzyme then develops in the steroidogenic cells. These results are compared with others obtained with estradiol and also in chick. The discussion deals also with the effects of these estrogens on the endogenous abilities and specific responses of the gonads in relation to sex differentiation factors.