Multifunctional PEG modified DOX loaded mesoporous silica nanoparticle@CuS nanohybrids as photo-thermal agent and thermal-triggered drug release vehicle for hepatocellular carcinoma treatment
Multifunctional PEG modified DOX loaded mesoporous silica nanoparticle@CuS nanohybrids as photo-thermal agent and thermal-triggered drug release vehicle for hepatocellular carcinoma treatment
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DOI：
10.1088/0957-4484/26/2/025102
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发表时间：
2015-01
期刊：
影响因子：
3.5
通讯作者：
Lingjie Wu;Ming Wu;Yongyi Zeng;Da Zhang;Aixian Zheng;Xiaolong Liu;Jingfeng Liu
中科院分区：
文献类型：
--
作者：
Lingjie Wu;Ming Wu;Yongyi Zeng;Da Zhang;Aixian Zheng;Xiaolong Liu;Jingfeng Liu
多种治疗模式与受控方式的结合是纳米医学的关键改进。本研究合成了聚乙二醇（PEG）修饰的阿霉素（DOX）介孔二氧化硅纳米粒子（MSN）@CuS纳米杂化物作为高效的药物递送载体，结合光热疗法和化疗来提高对肝细胞癌（HCC）的治疗效果。通过透射电子显微镜（TEM）、N2吸附和脱附实验以及可见-近红外吸收光谱对纳米杂化物的物理性质进行了表征。结果表明，阿霉素可以被储存在介孔二氧化硅纳米粒子的内孔中; CuS纳米粒子包覆在介孔二氧化硅纳米粒子表面，可以作为高效的光热治疗（PTT）剂;近红外辐射可以很容易地触发载药的释放。与任何单独的单一方法相比，PTT治疗与受控化疗的组合可以进一步增强癌症消融能力。因此，报道的PEG修饰的DOX负载介孔二氧化硅纳米粒子@CuS纳米杂化物可能是非常有前途的肝癌治疗剂。
The combination of a multi-therapeutic mode with a controlled fashion is a key improvement in nanomedicine. Here, we synthesized polyethylene glycol (PEG)-modified doxorubicin (DOX)-loaded mesoporous silica nanoparticle (MSN) @CuS nanohybrids as efficient drug delivery carriers, combined with photothermal therapy and chemotherapy to enhance the therapeutic efficacy on hepatocellular carcinoma (HCC). The physical properties of the nanohybrids were characterized by transmission electron microscopy (TEM), N2 adsorption and desorption experiments and by the Vis-NIR absorption spectra. The results showed that the doxorubicin could be stored in the inner pores of mesoporous silica nanoparticles; the CuS nanoparticles, which are coated on the surface of a mesoporous silica nanoparticle, could serve as efficient photothermal therapy (PTT) agents; the loaded drug release could be easily triggered by NIR irradiation. The combination of the PTT treatment with controlled chemotherapy could further enhance the cancer ablation ability compared to any of the single approaches alone. Hence, the reported PEG-modified DOX-loaded mesoporous silica nanoparticle@CuS nanohybrids might be very promising therapeutic agents for HCC treatment.