The association between level of brachial-ankle pulse wave velocity and onset of ADL impairment in community-dwelling older individuals
The association between level of brachial-ankle pulse wave velocity and onset of ADL impairment in community-dwelling older individuals
复制标题
社区老年人臂踝脉搏波速度水平与 ADL 损伤发生之间的关联
DOI：
10.1111/ggi.12356
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yasuda M
中科院分区：
文献类型：
--
作者：
Kuroiwa Y;Miyano I;Nishinaga M;Takata J;Shimizu Y;Okumiya K;Matsubayashi K;Ozawa T;Kitaoka H;Doi Y;Yasuda M
随着年龄的增长而增加的动脉僵硬是导致心血管疾病的原因。脉搏波速度（PWV）被认为是动脉硬度的一个指标，通常通过测定颈动脉-股动脉PWV （cfPWV）或肱-踝动脉PWV （baPWV）来评估。据报道，cfPWV和baPWV的增加与慢性疾病患者以及社区居民的总死亡或心血管死亡风险增加有关。在老年人中，不仅要预测死亡率，还要预测日常生活活动障碍（ADL）。在日本，导致ADL受损的主要原因包括脑血管疾病、痴呆、跌倒、骨折和废用综合征。据报道，由cfPWV测定的动脉僵硬度与卒中发生率、认知功能障碍患病率和大腿肌肉量减少有关。然而，目前还没有关于baPWV与ADL障碍发病之间关联的报道。因此，本研究的目的是评估在社区居住的老年人中，三年内baPWV水平与ADL障碍发病之间的关系。
Arterial stiffness, which increases with advancing age, is known to lead to cardiovascular disease. Pulse wave velocity (PWV), known as an indicator of arterial stiffness, is frequently assessed by determining carotid-femoral PWV (cfPWV) or brachial-ankle PWV (baPWV). Increased cfPWV and baPWV has been reported to be associated with increased risks of total or cardiovascular mortality in individuals with chronic conditions, as well as in community-dwelling individuals. In older individuals, it is important to predict not only mortality but also impairment in activities of daily living (ADL). In Japan, the major causes of impairment in ADL include cerebrovascular diseases, dementia, falls, fracture, and disuse syndrome. Arterial stiffness, as determined by cfPWV, has been reported to be associated with the incidence of stroke, prevalence of cognitive dysfunction and reduced thigh muscle mass. However, there are no reports regarding an association between baPWV and the onset of ADL impairment. The purpose of this study was therefore to evaluate the relationship between baPWV level and onset of ADL impairment during three-years among community-dwelling older individuals.