White matter microstructure correlates with mathematics but not word reading performance in 13-year-old children born very preterm and full-term
White matter microstructure correlates with mathematics but not word reading performance in 13-year-old children born very preterm and full-term
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DOI：
10.1016/j.nicl.2019.101944
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Anderson, Peter J.
中科院分区：
文献类型：
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作者：
Collins, Simonne E.;Spencer-Smith, Megan;Anderson, Peter J.
极早产儿（VPT;胎龄< 32周）与足月儿（FT;胎龄>= 37周）相比，其数学和文字阅读能力受损的风险增加，并且广泛的白色微结构改变也增加。迄今为止，学习成绩和白色物质微观结构之间的联系还没有得到很好的理解。本研究采用白色物质微结构的方法，对114名13岁VPT和36名FT儿童的数学和阅读成绩之间的关系进行了研究。此外，我们的目的是调查是否关联的数学和阅读性能与白色物质微结构的VPT儿童作为一个功能的损害。为此，我们使用了扩散张量成像和先进的扩散建模技术（神经突方向分散和密度成像和球面平均技术），结合全脑分析方法（基于区域的空间统计）。VPT和FT组的数学成绩与各向异性分数和神经突密度的白色物质显微结构测量呈正相关，与广泛双侧区域的径向和平均扩散率呈负相关。此外，与没有数学障碍的VPT儿童相比，有数学障碍的VPT儿童（低于FT平均值的标准差> 1）的神经突密度显著降低。阅读能力与任何白色物质的微结构参数均无显著相关性。此外，白色物质微结构与数学和阅读成绩之间的关联在VPT组和FT组之间没有显著差异。我们的研究结果表明，白色物质的微观结构的改变，更具体地说，较低的神经突密度，与13岁的VPT和FT儿童的数学成绩较差。13岁儿童阅读成绩与白色物质微结构之间的关系还需要更多的研究。
Individuals born very preterm (VPT; < 32 weeks' gestational age) are at increased risk of impaired mathematics and word reading performance, as well as widespread white matter microstructural alterations compared with individuals born full term (FT; >= 37 weeks' gestational age). To date, the link between academic performance and white matter microstructure is not well understood. This study aimed to investigate the associations between mathematics and reading performance with white matter microstructure in 114 VPT and 36 FT 13-year-old children. Additionally, we aimed to investigate whether the association of mathematics and reading performance with white matter microstructure in VPT children varied as a function of impairment. To do this, we used diffusion tensor imaging and advanced diffusion modelling techniques (Neurite Orientation Dispersion and Density Imaging and the Spherical Mean Technique), combined with a whole-brain analysis approach (TractBased Spatial Statistics). Mathematics performance across VPT and FT groups was positively associated with white matter microstructural measurements of fractional anisotropy and neurite density, and negatively associated with radial and mean diffusivities in widespread, bilateral regions. Furthermore, VPT children with a mathematics impairment ( > 1 standard deviation below FT mean) had significantly reduced neurite density compared with VPT children without an impairment. Reading performance was not significantly associated with any of the white matter microstructure parameters. Additionally, the associations between white matter microstructure and mathematics and reading performance did not differ significantly between VPT and FT groups. Our findings suggest that alterations in white matter microstructure, and more specifically lower neurite density, are associated with poorer mathematics performance in 13-year-old VPT and FT children. More research is required to understand the association between reading performance and white matter microstructure in 13-year-old children.