Explicit and implicit facial affect recognition in manic and depressed states of bipolar disorder: A functional magnetic resonance imaging study
Explicit and implicit facial affect recognition in manic and depressed states of bipolar disorder: A functional magnetic resonance imaging study
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DOI：
10.1016/j.biopsych.2005.06.008
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发表时间：
2006-01-01
影响因子：
10.6
通讯作者：
Bullmore, ET
中科院分区：
文献类型：
--
作者：
Chen, CH;Lennox, B;Bullmore, ET
背景：双相情感障碍患者的异常情绪状态-躁狂和抑郁-的病理生理学尚不清楚。面部情感加工范式是研究行为和功能磁共振成像（fMRI）相关的情感disorders.Methods的有效途径：我们使用了析因设计来测量任务的神经相关性，利用事件相关的fMRI范式在三组参与者中挖掘悲伤，恐惧和快乐面部表情的外显和内隐识别：8例双相抑郁症患者，8例双相躁狂症患者和8例对照组。抑郁症和躁狂症患者对恐惧的面孔以及情绪不一致的面部表情表现出过度激活的反应，其中抑郁组在额-纹状体-丘脑系统中表现出对快乐面孔的过度活跃，而躁狂组在梭状回中表现出对悲伤面孔的过度活跃。对于躁狂症患者，任务类型也影响神经反应的悲伤的面孔，与皮质边缘区表现出过度激活的内隐加工和激活不足的外显processing.Conclusions：抑郁症和躁狂症患者表现出异常的神经反应悲伤，恐惧，和快乐的面部表情。此外，悲伤面部情绪处理的注意水平对躁狂患者杏仁核和扣带回激活异常有重要影响。
Background: The pathophysiology of abnormal mood states-mania and depression-in patients with bipolar disorder remains unclear. Facial affect processing paradigms are an effective way of studying behavioral and functional magnetic resonance imaging (fMRI) correlates of affective disorders.Methods: We used a factorial design to measure the neural correlates of tasks, tapping explicit and implicit recognition of sad, fearful, and happy facial expressions using event-related fMRI paradigms in three groups of participants: eight bipolar depressed patients, eight bipolar manic patients, and eight control subjects.Results: Depressed and manic patients exhibited overactivated responses to fearful faces, as well as to mood-incongruent facial expressions, with the depressed group exhibiting overactivity in fronto-striato-thalamic systems in response to happy faces and the manic group exhibiting overactivity in the fusiform gyrus in response to sad faces. For manic patients, task type also affected the neural response to sad faces, with the corticolimbic regions showing overactivation for implicit processing and underactivation for explicit processing.Conclusions: Depressed and manic patients exhibited abnormal neural responses to sad, fearful, and happy facial expressions. Additionally, the attentional level of sad facial affect processing has important consequences for abnormalities of amygdala and cingulate activation in manic patients.