Synchronization to auditory and visual beats in Parkinson's disease
Synchronization to auditory and visual beats in Parkinson's disease
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帕金森病的听觉和视觉节拍同步
DOI：
10.1016/j.parkreldis.2020.08.029
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发表时间：
2020
影响因子：
4.1
通讯作者：
Wu Xiang
中科院分区：
文献类型：
--
作者：
Wu Qian;Zhou Yuntao;Li Minying;Mei Xiaolin;Wu Youliang;Fu Wenbin;Wu Xiang
与感知到的规则节拍同步移动的能力对于人类以预期的方式与环境交互是必不可少的，并且基底神经节已被证明优先参与节拍处理。以基底神经节功能障碍为特征的帕金森病（PD）患者的感觉运动功能障碍常采用听觉搏动进行评估。而节拍同步长期以来一直被认为是特定的听觉模态，最近的研究采用移动而不是静态的视觉刺激已经显示出可比的听觉和视觉节拍的同步性能。在这里，我们发现，与对照组相比，PD患者的同步稳定性显着下降的节拍组成的视觉收缩环，但不为节拍组成的听觉音调或静态视觉闪光。结果显示PD患者的视觉节拍同步性存在特异性损害。考虑到PD患者在日常生活中的视觉交互的共同经验，本研究结果强调了通过采用具有生态相关性的移动视觉刺激来评估PD中视觉时序缺陷的重要性。
The ability to move in synchrony with a perceived regular beat in time is essential for humans to interact with environments in an anticipatory manner, and the basal ganglia have been shown to be preferentially involved in beat processing. Auditory beats are often adopted in assessing the sensorimotor deficiency of patients with Parkinson's disease (PD), which is characterized by basal ganglia dysfunction. Whereas beat synchronization has long been considered to be specific to the auditory modality, recent studies employing moving instead of static visual stimuli have shown comparable synchronization performances of auditory and visual beats. Here, we show that compared with control subjects, synchronization stability of PD patients significantly decreased for beats composed of visual contracting rings but not for beats consisting of auditory tones or static visual flashes. The results revealed specific impairment of visual beat synchronization in PD. Considering the common experience of visuomotor interactions in daily lives of PD patients, the present finding emphasizes the importance of evaluation of visuomotor timing deficiency in PD by employing moving visual stimuli that have ecological relevance.