Classification of secondary amenorrhea based on distinct hormonal patterns.
Classification of secondary amenorrhea based on distinct hormonal patterns.
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根据不同的激素模式对继发性闭经进行分类。
DOI：
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发表时间：
1975
影响因子：
5.8
通讯作者：
D. Mishell
中科院分区：
文献类型：
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作者：
O. Kletzky;V. Davajan;R. Nakamura;D. Mishell
继发性闭经患者临床分为4组。为了进一步研究这4组患者，我们对21例继发性闭经患者每隔15 min测定一次LH、FSH和雌二醇（E2）水平，每隔4 h测定一次。每组患者的激素模式相似，但组间差异明显。1组（多囊卵巢[PCO]） 3例患者仅有LH基础水平升高，且有明显的不规则波动。II组（下丘脑-垂体功能障碍）7例患者LH、FSH和E2基础水平正常。只有LH表现出不同幅度和频率的振荡。III组8例患者（下丘脑-垂体功能衰竭）LH、FSH和E2水平较低或低于正常水平，波动极小或无波动。IV组（卵巢功能衰竭）中有3例患者FSH和LH基础水平高且不规则波动。本研究证实继发性闭经患者分为4组的合理性。此外，我们还发现，在III组患者中，即使单个样本在正常范围内，4小时内LH的分泌总量似乎也不足以刺激卵巢产生E2。
Patients with secondary amenorrhea have been classified into 4 clincal groups. In order to further investigate these 4 groups, LH, FSH, and estradiol (E2) were measured at 15 min intervals for 4 h in 21 patients with secondary amenorrhea. Patients within each group had similar hormonal patterns, but there was a distinct variation among the groups. Three patients in group 1 (polycystic ovaries [PCO]) had elevated basal levels of only LH with marked irregular fluctuations. Seven patients in group II (hypothalamic-pituitary dysfunction) had normal basal levels of LH, FSH, and E2. Only LH showed oscillations of varying mahnitude and frequency. Eight patients in group III (hypothalamic-pituitary failure) had low or low-normal levels of LH, FSH, and low E2 with minimal or absent fluctuations. Three patients in group IV (ovarian failure) had high basal levels of FSH and LH and irregular fluctuations. This study confirmed the rationality of separating patients with secondary amenorrhea into 4 different groups. In addition, it was found that in group III patients, the total amount of LH secreted in a 4-hour period of time appears to be insufficient to stimulate E2 production from the ovary even when a single sample was found to be in the normal range.