Longevity-associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men
Longevity-associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men
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DOI：
10.1111/j.1442-9071.2004.00796.x
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发表时间：
2004-04-01
影响因子：
4
通讯作者：
Takashima, Y
中科院分区：
文献类型：
--
作者：
Kokaze, A;Yoshida, M;Takashima, Y
背景资料：线粒体DNA 5178腺嘌呤/胞嘧啶（mt5178 A/C）多态性已被报道与日本人的长寿相关，实验结果得出结论，mt5178 A是一种抗动脉粥样硬化基因型。本研究的目的是确定mt5178 A/C基因多态性是否影响眼内压（IOP），以及其与动脉硬化的关系。方法：选择1999年8月至2000年8月在某综合医院体检的男性志愿者449名。其中，386名未接受任何高血压、高眼压或青光眼药物治疗的日本男性被选为本研究的受试者。在这些受试者进行基因分型后，关于基因型和IOP之间的关系的横断面研究carried.Results：平均IOP是显着高于男性与mt5178 C（13.3 mmHg）比那些与mt5178 A（12.7 mmHg）（P = 0.037）。在调整年龄、体重指数、血压、习惯性吸烟和习惯性饮酒后，两种基因型之间的平均IOP的显著差异仍然明显。观察mt5178 A/C多态性与习惯性吸烟或每日饮酒对IOP的影响。多因素回归分析显示，线粒体DNA 5178 A/C多态性与日本男性的眼压相关，而线粒体DNA 5178 A/C多态性与日本男性的眼压相关，线粒体DNA 5178 A/C多态性与日本男性的眼压相关。
Background: Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism has been reported to be associated with longevity in Japanese individuals, with experimental findings concluding that mt5178 A is an anti-atherogenic genotype. The aim of this study was to determine whether mt5178 A/C polymorphism influences intraocular pressure (IOP), and its relationship with the development of arteriosclerosis.Methods: Four hundred and forty-nine male volunteers who had visited a general hospital for medical check-up between August 1999 and August 2000 were enrolled. Of these, 386 Japanese men who had not undergone any medical treatment for hypertension, ocular hypertension or glaucoma were selected as subjects of this study. After these subjects were genotyped, a cross-sectional study regarding the relationship between genotype and IOP was conducted.Results: Mean IOP was significantly higher in men with mt5178 C (13.3 mmHg) than in those with mt5178 A (12.7 mmHg) (P = 0.037). This significant difference in mean IOP between the two genotypes remained evident after adjusting for age, body mass index, blood pressure, habitual smoking and habitual drinking. Interactions between mt5178 A/C polymorphism and habitual smoking or daily alcohol consumption with regard to IOP were observed. According to multiple regression analysis, habitual smoking was significantly associated with IOP in men with mt5178 A (P for trend = 0.020), while daily alcohol consumption was significantly associated with IOP in those with mt5178 C (P for trend = 0.021).Conclusion: Longevity-associated mitochondrial DNA 5178 A/C polymorphism may be associated with IOP in Japanese men.