Immunomodulatory effect of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi grown in high-salt medium
Immunomodulatory effect of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi grown in high-salt medium
复制标题
DOI：
10.1016/j.ijfoodmicro.2007.10.011
复制
发表时间：
2008-02-10
影响因子：
5.4
通讯作者：
Nishimura, Ikuko
中科院分区：
文献类型：
--
作者：
Masuda, Susumu;Yamaguchi, Hitomi;Nishimura, Ikuko
嗜盐乳酸菌Tetragenococcus halophilus除了在酱料酿造中发挥重要作用外，还具有促进T辅助细胞1型（Th 1）免疫的免疫调节活性。菌株Th 221是从分离自酱料（酱油）Moromi的151个菌株中选择的，因为其在体外诱导小鼠腹腔巨噬细胞产生强的白细胞介素（IL）-12。研究了培养基中的盐浓度与该菌株的IL-12产生诱导活性之间的关系，发现当细菌在含有>= 10%（w/v）盐的培养基中生长时，该活性强。Th 1-促进活性也表现在体内小鼠研究中，因为Th 1-依赖性接触敏感性增强和Th 2免疫，如通过特异性免疫球蛋白E产生所评估的，在口服摄入Th 221后被抑制。基于这些发现，Th 221给药可能有助于改善过敏症状。(C)2007 Elsevier B. V.保留所有权利。
A halophilic lactic acid bacterium, Tetragenococcus halophilus, was found to possess an immunomodulatory activity that promotes T helper type 1 (Th 1) immunity in addition to its important roles in soy sauce brewing. Strain Th221 was selected from 151 strains isolated from soy sauce (shoyu) moromi, since it induced strong interleukin (IL)-12 production by mouse peritoneal macrophages in vitro. The relationship between the salt concentration in the medium and the IL-12 production-inducing activity of this strain was investigated, and the activity was found to be strong when the bacteria were grown in medium containing >= 10% (w/v) salt. The Th1-promoting activity was also manifested in an in vivo mouse study, since Th1-dependant contact sensitivity was augmented and Th2 immunity, as evaluated by specific immunoglobulin E production, was suppressed following oral ingestion of Th221. Based on these findings, Th221 administration may be useful for improving allergic symptoms. (C) 2007 Elsevier B.V. All rights reserved.