Rapid G0/1 transition and cell cycle progression in CD8+ T cells compared to CD4+ T cells following in vitro stimulation
Rapid G0/1 transition and cell cycle progression in CD8+ T cells compared to CD4+ T cells following in vitro stimulation
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DOI：
10.1111/1348-0421.12479
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发表时间：
2017-05
影响因子：
2.6
通讯作者：
T. Mishima;S. Fukaya;Shoko Toda;Yoshiaki Ando;T. Matsunaga;M. Inobe
中科院分区：
文献类型：
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作者：
T. Mishima;S. Fukaya;Shoko Toda;Yoshiaki Ando;T. Matsunaga;M. Inobe
T细胞群由两个主要亚群组成，即CD 4 + T细胞和CD 8 + T细胞，它们可以分别通过CD 4或CD 8分子的表达来区分。虽然它们在免疫系统中发挥着非常不同的作用，但它们的许多基本细胞过程（如刺激后的增殖）可能是共同的。在这项研究中，我们仔细分析了体外生长刺激后静止T细胞群的两个亚群中G 0/1转换的时间过程以及细胞周期进展。我们发现，与CD 4 + T细胞相比，CD 8 + T细胞更快地促进G 0/1转换，并更快地驱动其细胞周期进程。此外，CD 25的表达及其阻断的效果表明，IL-2与CD 8 + T细胞的快速进展有关，但与早期的G 0/1转换无关。
T‐cell population consists of two major subsets, CD4+ T cells and CD8+ T cells, which can be distinguished by the expression of CD4 or CD8 molecules, respectively. Although they play quite different roles in the immune system, many of their basic cellular processes such as proliferation following stimulation are presumably common. In this study, we have carefully analyzed time–course of G0/1 transition as well as cell cycle progression in the two subsets of quiescent T‐cell population following in vitro growth stimulation. We found that CD8+ T cells promote G0/1 transition more rapidly and drive their cell cycle progression faster compared to CD4+ T cells. In addition, expression of CD25 and effects of its blockade revealed that IL‐2 is implicated in the rapid progression, but not the earlier G0/1 transition, of CD8+ T cells.