New Obesity Indices and Adipokines in Normotensive Patients and Patients With Hypertension Comparative Pilot Analysis
New Obesity Indices and Adipokines in Normotensive Patients and Patients With Hypertension Comparative Pilot Analysis
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DOI：
10.1177/0003319713485807
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发表时间：
2014-04-01
期刊：
影响因子：
2.8
通讯作者：
Rysz, Jacek
中科院分区：
文献类型：
--
作者：
Stepien, Mariusz;Stepien, Anna;Rysz, Jacek
我们比较了肥胖伴高血压患者和血压正常患者的肥胖参数和选定的脂肪因子-瘦素、脂联素和抵抗素。将67例非糖尿病肥胖门诊患者分为2组：A-高血压组和B-血压正常组。测定血清瘦素、脂联素、β-内酰胺酶和胰岛素水平。测量体重、身高、腰围和臀围，计算腰臀比（WHR）、体重身高比、内脏脂肪指数和身体脂肪指数（BAI）。在高血压患者中，观察到瘦素与体重指数和BAI之间的显著正相关（分别为r = .31和r = .63）。在血压正常的患者中，瘦素与BAI呈正相关与腰臀比呈负相关（r = .73，P < .01）脂联素与腰臀比呈负相关（r = -.55，P < .0001），脂联素与BAI呈负相关（r =-.38，P <.01），脂联素与腰臀比呈负相关（r = -.36，P < .05）。结论：肥胖患者内脏型肥胖和瘦素与高血压相关。
We compared the obesity parameters and selected adipokines-leptin, adiponectin, and resistin-in obese patients with hypertension and normotensive patients. A total of 67 nondiabetic obese outpatients were divided into 2 groups: A-hypertensive and B-normotensive. Serum levels of leptin, adiponectin, resistin, and insulin were measured. Weight, height, waist circumference, and hip circumference were measured to calculate waist-to-hip ratio (WHR), weight-to-height ratio, visceral adiposity index, and body adiposity index (BAI). Among patients with hypertension, significant positive correlations were observed between leptin and body mass index and BAI (r = .31 and r = .63, respectively). In normotensive patients, leptin positively correlated with BAI (r = .73, P < .01) and negatively with WHR (r = -.55, P < .0001); adiponectin negatively correlated with WHR (r = .38, P < .01) and BAI (r = .52; P < .0001), and resistin negatively correlated with WHR (r = -.36, P < .05). In conclusion, visceral obesity and leptin are associated with hypertension in obese patients.