SEIZURE THRESHOLD IN ELECTROCONVULSIVE-THERAPY (ECT) .2. THE ANTICONVULSANT EFFECT OF ECT
SEIZURE THRESHOLD IN ELECTROCONVULSIVE-THERAPY (ECT) .2. THE ANTICONVULSANT EFFECT OF ECT
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DOI：
10.1016/0006-3223(95)00053-j
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发表时间：
1995-06-01
影响因子：
10.6
通讯作者：
AQUE, M
中科院分区：
文献类型：
--
作者：
COFFEY, CE;LUCKE, J;AQUE, M
为了测量一个疗程的电休克治疗（ECT）的抗惊厥作用，我们使用了一个灵活的刺激剂量滴定程序，以估计癫痫发作阈值在第一次和第六次ECT治疗62例抑郁症患者谁正在经历一个疗程的短脉冲，恒定电流ECT给予中度阈上刺激强度。癫痫发作阈值平均增加约47%，但62例患者中仅35例（56%）显示癫痫发作阈值升高。癫痫发作阈值的升高与年龄的增加有关，但与性别刺激电极放置或初始癫痫发作阈值无关。从第1次到第6次ECT治疗，动态阻抗下降约5%，但动态阻抗的变化与癫痫发作阈值的升高无相关性，癫痫发作阈值的升高与ECT治疗的反应状态和反应速度均无相关性;这些发现证实了ECT的抗惊厥作用，但表明这种作用并不紧密耦合到适度阈上ECT的治疗效果。
To measure the anticonvulsant effects of a course of electroconvulsive therapy (ECT) we used a flexible stimulus dosage titration procedure to estimate seizure threshold at the first and sixth ECT treatments in 62 patients with depression who were undergoing a course of brief pulse, constant current ECT given at moderately suprathreshold stimulus intensity. Seizure threshold increased by approximately 47% on average, but only 35 (56%) of the 62 patients showed a rise in seizure threshold. The rise in seizure threshold was associated with increasing age, but not with gender stimulus electrode placement, or initial seizure threshold. Dynamic impedance decreased by approximately 5% from the first to the sixth ECT treatment, but there was no correlation between the change in dynamic impedance and the rise in seizure threshold, No relation was found between the rise in seizure threshold and either therapeutic response status or speed of response to the ECT treatment course; These findings confirm the anticonvulsant effect of ECT but suggest that such effects are not tightly coupled to the therapeutic efficacy of moderately suprathreshold ECT.