Cerium (IV) ammonium nitrate (CAN) as a catalyst in tap water: A simple, proficient and green approach for the synthesis of quinoxalines
Cerium (IV) ammonium nitrate (CAN) as a catalyst in tap water: A simple, proficient and green approach for the synthesis of quinoxalines
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DOI：
10.1039/b510677j
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发表时间：
2006-01-01
期刊：
影响因子：
9.8
通讯作者：
Yao, CF
中科院分区：
文献类型：
--
作者：
More, SV;Sastry, MNV;Yao, CF
利用硝酸铈铵（CAN）在水中的催化量，合成了多种具有重要生物学意义的喹诺啉衍生物。这种廉价、无毒、易得的催化体系（5 mol%）在水中有效地催化各种1,2-二酮和1,2-二胺的缩合反应。几种芳香和脂肪族1,2-二酮和芳香1,2-二胺，如取代苯二胺和四胺，进一步用催化量的CAN进行缩合，得到收率很高的产物。除此之外，环境条件，优异的产品收率和水作为通用溶剂显示出经济和环境优势。
Various biologically important quinoxaline derivatives have been efficiently synthesized in excellent yields using catalytic amounts of cerium (iv) ammonium nitrate (CAN) in water. This inexpensive, nontoxic, and readily available catalytic system (5 mol%) in water efficiently catalyzes the condensation reaction of various 1,2-diketones and 1,2-diamines. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines such as substituted phenylene diamines, and tetra amines were further subjected to condensation using catalytic amounts of CAN to yield the products in excellent yield. Besides this, ambient conditions, excellent product yields and water as a universal solvent display both economic and environmental advantages.