Static lung-lung interactions in unilateral emphysema.
Static lung-lung interactions in unilateral emphysema.
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单侧肺气肿中的静态肺-肺相互作用。
DOI：
10.1152/jappl.1992.73.2.545
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Hubmayr,RD
中科院分区：
文献类型：
--
作者：
Margulies,SS;Schriner,RW;Schroeder,MA;Hubmayr,RD
在将单肺移植引入临床实践的推动下，我们比较了六只仰卧犬在单侧肺气肿诱导前（基线）和诱导后的呼吸系统的静态机械特性。肺气肿肺的舒张量 (Vrel)、总肺活量 (TLC) 和静态顺应性分别增加至基线的 214 +/- 68、186 +/- 39 和 253 +/- 95% (SD)。非气肿肺的 Vrel 降至基线的 81 +/- 28%，非气肿肺的 TLC 或其压力-容积关系没有显着变化，表明单侧过度充气不会导致对侧肺单位脱落。单侧肺气肿后，六只动物中的三只的胸壁转移到更高的无应力或中性体积（当胸膜压力等于大气压时），从而最大限度地减少了较高呼吸系统 Vrel 肺反冲压力的预期下降。在 TLC 逐步放气过程中，完整狗和切除肺的相对肺排空模式相似，表明半胸的平均胸膜压相等。我们得出的结论是，在狗中，肺气肿和非气肿肺之间的静态体积分布仅由肺回缩和顺应性的差异决定。
Motivated by the introduction of single-lung transplantation into clinical practice, we compared the static mechanical properties of the respiratory system in six supine dogs before (at baseline) with those after the induction of unilateral emphysema. Relaxation volume (Vrel), total lung capacity (TLC), and static compliance of the emphysematous lung increased to 214 +/- 68, 186 +/- 39, and 253 +/- 95% (SD) of baseline, respectively. Vrel of the nonemphysematous lung fell to 81 +/- 28% of baseline, with no significant change in TLC of the nonemphysematous lung or its pressure-volume relationship, indicating that unilateral hyperinflation does not cause dropout of contralateral lung units. After unilateral emphysema, the chest wall shifted to a higher unstressed or neutral volume (when pleural pressure equals atmospheric pressure) in three of six animals, minimizing the anticipated decrease in lung recoil pressure at the higher respiratory system Vrel. The pattern of relative lung emptying in the intact dog and in the excised lungs was similar during stepwise deflations from TLC, suggesting that mean pleural pressure of the hemithoraces is equal. We conclude that in the dog the static volume distribution between emphysematous and nonemphysematous lungs is determined only by differences in lung recoil and compliance.