Quantitative analysis of retinal function in early stages of retinal degeneration in the rd1 mouse
Quantitative analysis of retinal function in early stages of retinal degeneration in the rd1 mouse
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DOI：
10.17077/etd.ipizeeoq
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发表时间：
2010
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影响因子：
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通讯作者：
E. Nylen
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作者：
E. Nylen
Nylen, Erik Lee。rd1小鼠视网膜变性早期视网膜功能的定量分析。我最关心的是如何称呼它。我本想叫它“信息”，但这个词被滥用了，所以我决定叫它“不确定性”。当我和约翰·冯·诺伊曼讨论这个问题时，他有一个更好的主意。冯·诺伊曼告诉我，“你应该把它叫做熵，原因有二。首先，你的不确定性函数已经在统计力学中使用了这个名字，所以它已经有了一个名字。其次，更重要的是，没有人知道熵到底是什么，所以在辩论中你总是占上风。”我感谢Edwin Dove博士，从我踏上爱荷华大学校园的第一天起，他就一直是我的杰出导师，为我提供了很多支持。我非常感谢对我个人和专业兴趣的支持。在每个关键时刻都帮助过我。我感谢我所有的朋友，尤其是舞蹈马拉松和ICHI的朋友们，感谢他们多年来给予我的支持。我要特别感谢我的哥哥保罗，没有他，我就不可能完成这篇论文；我还要感谢爸爸妈妈、爷爷奶奶、堂兄弟姐妹、叔叔阿姨，感谢他们对我的每一次冒险都坚定不移的支持，不管我的道路看起来有多远。在这篇论文中，我使用了计算神经科学、通信理论和电生理学的一系列技术来表征小鼠视网膜变性早期阶段发生的功能变化。在出生后第14天，rd1小鼠的视网膜神经节细胞与年龄匹配的对照组表现出特殊的差异：对光刺激的反应延迟增加，对光刺激的反应尖峰计数减少，自发放电活动增加，信息传递减少。我认为这是由于OFF双极细胞兴奋的上调，这是在rd1中看到的功能变化的关键因素，并使用创新技术来发现支持这些说法的发现。
Recommended Citation Nylen, Erik Lee. "Quantitative analysis of retinal function in early stages of retinal degeneration in the rd1 mouse. iii My greatest concern was what to call it. I thought of calling it 'information,' but the word was overly used, so I decided to call it 'uncertainty.' When I discussed it with John von Neumann, he had a better idea. Von Neumann told me, 'You should call it entropy, for two reasons. In the first place your uncertainty function has been used in statistical mechanics under that name, so it already has a name. In the second place, and more important, nobody knows what entropy really is, so in a debate you will always have the advantage.' Claude Shannon Scientific American iv ACKNOWLEDGMENTS I thank Dr. Edwin Dove for serving as an outstanding adviser and providing me with much support since the first day I set foot on campus at Iowa. I give many thanks to support of my personal and professional interests. have helped me at each juncture. I thank all of my friends, notably those in Dance Marathon and ICHI, for much needed support over the years. I give the highest acknowledgment to my brother, Paul, without whom I would have never accomplished any of this thesis, as well as Mom, Dad, my grandparents, cousins, aunts, and uncles, for their unwavering support of my every venture, no matter how far off the path it may seem. v ABSTRACT In this thesis, I use a range of techniques in computational neuroscience, communication theory, and electrophysiology to characterize functional changes that occur in early stages of retinal degeneration in the mouse. At post natal day 14, retinal ganglion cells in the rd1 mouse exhibit peculiar differences from age matched controls: an increased latency of responses to the onset of a light stimulus, decreased spike count in response to stimulus onset, increased spontaneous firing activity, and a decrease in information transmission. I propose this is due to an up-regulation of OFF bipolar cell excitation, a critical factor in functional changes seen in rd1, and use innovative techniques to discover findings that support these claims.