Bioactive Ergost-5-ene-3β/,7α-diol Derivatives from Pseudobersama mossambicensis
Bioactive Ergost-5-ene-3β/,7α-diol Derivatives from Pseudobersama mossambicensis
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莫桑比克拟生物活性麦角素-5-烯-3β/,7α-二醇衍生物
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
Randall K. Johnson
中科院分区：
文献类型：
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作者：
A. Gunatilaka;G. Samaranayake;D. Kingston;G. Hoffmann;Randall K. Johnson
对莫桑比克拟灯心草的甲基乙基酮提取物进行生物活性定向分馏，分离出麦角甾-5，24（28）-二烯-3 β，7 α-二醇[1]、24，28-环氧麦角甾-5-烯-3 β，7 α-二醇[2]和麦角甾-5-烯-3 β，7 α，24，28-四醇[3]。所有三个甾醇对DNA修复缺陷的酵母突变体显示出选择性活性。甾醇1也显示出对野生型P-388小鼠白血病细胞的细胞毒性。报道了这些甾醇的分离、结构鉴定和生物活性。甾醇3很可能是在分离过程中由甾醇2形成的人工产物。
Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3 beta,7 alpha-diol [1], 24,28-epoxyergost-5-ene-3 beta,7 alpha-diol [2], and ergost-5-ene-3 beta,7 alpha,24,28-tetraol [3]. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.