RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
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RNA在意外的地方：长的非编码RNA在不同的细胞环境中起作用。
DOI：
10.1038/nrm3679
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发表时间：
2013-11
期刊：
影响因子：
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通讯作者：
Coller J
中科院分区：
文献类型：
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作者：
Geisler S;Coller J
全转录组分析方法的应用越来越多，导致记录的长非编码RNA（lncRNA）数量激增。虽然这些新的和神秘的球员在复杂的转录环境中编码的基因组的显着比例，他们的功能大多是未知的。早期的发现支持lncRNA通过染色质调节来调节转录的范例，但新的功能正在稳步出现。鉴于RNA的生物化学多功能性，lncRNA可用于各种任务，包括转录后调节、蛋白质复合物的组织、细胞-细胞信号传导和蛋白质的变构调节。
The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.