RELATION OF BURKITTS TUMOR-ASSOCIATED HERPES-TYPE VIRUS TO INFECTIOUS MONONUCLEOSIS
RELATION OF BURKITTS TUMOR-ASSOCIATED HERPES-TYPE VIRUS TO INFECTIOUS MONONUCLEOSIS
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DOI：
10.1073/pnas.59.1.94
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发表时间：
1968-01-01
影响因子：
11.1
通讯作者：
DIEHL, V
中科院分区：
文献类型：
--
作者：
HENLE, G;HENLE, W;DIEHL, V
传染性单核细胞增多症（IM）患者经常产生疱疹型病毒（EB病毒，EBV）抗体，该病毒存在于伯基特肿瘤或造血系统其他细胞的培养物中。这些抗体持续多年，与嗜异性抗体不同。IM的流行病学和EBV的血清流行病学有许多共同特征，因此EBV或其近亲可能是IM的病因。这一结论并不排除EBV也可能直接或间接参与伯基特淋巴瘤的病因学的可能性。
Patients with infectious mononucleosis (IM) regularly develop antibodies to the herpes-type virus (Epstein-Barr virus, EBV) found in cultures derived from Burkitt''s tumors or other cells of the hemato-poietic system. The antibodies persist for many years and are distinct from heterophile antibodies. The epidemiology of IM and the seroepidemiology of EBV share many features, so that EBV, or a close relative of it, may be the cause of IM. This conclusion does not preclude the possibility that EBV might also be involved, either directly or indirectly, in the etiology of Burkitt''s lymphoma.