Salidroside inhibits MAPK, NF-kappaB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
Salidroside inhibits MAPK, NF-kappaB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
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DOI：
10.1080/13510002.2019.1658377
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发表时间：
2019-12-01
期刊：
影响因子：
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通讯作者：
Deng, Yongqiong
中科院分区：
文献类型：
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作者：
Xu, Fengli;Xu, Jixiang;Deng, Yongqiong
目的：揭示SIRT1在限制银屑病氧化应激中的作用，并进一步探讨红景天苷治疗银屑病的前景。方法：以“银屑病”、“氧化应激”、“SIRT1”、“红景天苷”为关键词检索2002年至2019年的文献。然后总结了银屑病中的氧化应激和SIRT1的作用，并推测红景天苷在银屑病中的潜在作用。结果：氧化应激可能有助于银屑病的发病机制。氧化应激过程中产生的高水平活性氧会导致炎症介质的释放，进而诱导血管生成和角质形成细胞的过度增殖。 SIRT1是sirtuin家族的一员，其激活导致氧化应激信号通路MAPK、NF-κB和STAT3等氧化应激信号通路的抑制，下调炎症因子，抑制炎症和角质形成细胞过度增殖，并抑制血管生成。红景天的主要成分红景天苷具有抗氧化作用，这归因于 SIRT1 的激活。结论：红景天苷可能通过 SIRT1 激活抑制氧化应激信号转导通路，可作为治疗银屑病的理想候选药物。
Objectives: To unveil the role of SIRT1 in limiting oxidative stress in psoriasis and to further discuss the therapeutic prospects of salidroside in psoriasis. Methods: Literature from 2002 to 2019 was searched with "psoriasis", "oxidative stress", "SIRT1", "salidroside" as the key words. Then, Oxidative stress in psoriasis and the role of SIRT1 were summarized and the potential role of salidroside in the disease was speculated. Results: Oxidative stress might contribute to the pathogenesis of psoriasis. High levels of ROS produced during oxidative stress lead to the release of inflammatory mediators, that, in turn, induce angiogenesis and excessive proliferation of keratinocytes. SIRT1 is a member of the sirtuin family, of which the activation lead to the inhibition of such oxidative stress signaling pathways MAPK, NF-kappaB, and STAT3, down-regulation of inflammatory factors, suppression of inflammation and keratinocyte hyperproliferation, and inhibition of angiogenesis. Salidroside, the main ingredient of Rhodiola, is known to exert antioxidant roles, which has been attributed to SIRT1 activation. Conclusion: Salidroside might inhibit oxidative stress singling pathways via SIRT1 activation, and could be as an ideal candidate for management of psoriasis.