Biosensor Encapsulation via Photoinitiated Chemical Vapor Deposition (piCVD)
Biosensor Encapsulation via Photoinitiated Chemical Vapor Deposition (piCVD)
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DOI：
10.1149/1945-7111/ac1705
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发表时间：
2021-07
影响因子：
3.9
通讯作者：
Ruolan Fan;Trisha L. Andrew
中科院分区：
文献类型：
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作者：
Ruolan Fan;Trisha L. Andrew
采用光引发化学气相沉积（piCVD）法在光电葡萄糖传感器上制备了薄而多孔的聚（丙烯酸羟乙酯）（pHEA）和聚（丙烯酸3，3，4，4，5，5，6，6，7，7，8，8，8-十三氟辛酯）（pTFOA）封装层。这种表面限制的链生长过程提供了均匀的覆盖和所得聚合物封装层的强界面粘附，这使得整个感测区域被完全覆盖，即使在经受多次电化学扫描循环之后。同时，非晶薄膜允许快速离子和分析物扩散通过自己，因此，实现了快速的传感响应。特别是，pTFOA承诺良好定义的校准曲线具有良好的重复性。此外，piCVD膜在脱水和再水化多天后保持其形态，证明其作为表面保护层的优异稳定性。通过piCVD合成的pHEA和pTFOA的这些有前途的特性可以作为一种新的封装思想，应用于具有不同基底的各种可穿戴传感器，并作为一种新的策略，以延长生物传感器的保质期和功能。
Thin and porous poly(hydroxyethyl acrylate) (pHEA) and poly(3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctyl acrylate) (pTFOA) encapsulating layers were successfully deposited on model electrical and optical glucose sensors via photoinitiated chemical vapor deposition (piCVD). This surface-restricted chain growth process afforded uniform coverage and strong interfacial adhesion of the resulting polymer encapsulation layers, which enabled the whole sensing area to be fully covered, even after being subjected to numerous electrochemical scanning cycles. Meanwhile, the amorphous films allowed rapid ion and analyte diffusion through themselves and, therefore, achieved quick sensing responses. Especially, pTFOA promised well-defined calibration curves with good repeatability. Furthermore, piCVD films maintained their morphology after being dehydrated and rehydrated over multiple days demonstrating their excellent stability as surface protective layers. These promising features of pHEA and pTFOA synthesized via piCVD may serve as a new encapsulating idea to be applied to various wearable sensors with different substrates and serve as a new strategy to extend the shelf life and functionality of biosensors.