In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
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发表时间：
2004-08
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通讯作者：
Jianfei Guo;K. Higashi;H. Yokota;Y. Nagao;Y. Ueda;Y. Kodama;M. Oguchi;S. Taki;H. Tonami;I. Yamamoto
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作者：
Jianfei Guo;K. Higashi;H. Yokota;Y. Nagao;Y. Ueda;Y. Kodama;M. Oguchi;S. Taki;H. Tonami;I. Yamamoto
据报道，(18)F-FDG摄取、乳酸浓度和胆碱浓度是几种不同类型肿瘤恶性程度的良好指标。在这项研究中，我们研究了~(18)F-FDG PET显像中~(18)F-FDG摄取、体外(1)H磁共振波谱(MRS)测定的乳酸浓度和胆碱浓度与人肺腺癌生存概率的关系。方法19例肺腺癌患者术前行18F-FDGPET检查。从肺腺癌和正常肺的甲醇-氯仿-水提取液中获得了(1)H-MRS波谱。将同一患者肺腺癌与正常肺组织的乳酸(R(Lac))和胆碱(R(Cho))浓度比值与平均标准摄取值(SUV)进行相关分析。采用Kaplan-Meier寿命表法分析18F-FDG摄取、R(Lac)、R(Cho)与患者生存概率的关系。结果肺腺癌患者的平均SUV与R(Lac)、R(Cho)无明显相关性。SUV>；5意味着肺腺癌患者的生存概率较低(P=0.004)。较高的R(Lac)可能预示着肺腺癌患者的生存概率较低；然而，R(Cho)不是生存概率的指标。(18)F-FDG摄取量与细胞分化程度显著相关(P=0.007)，而R(Lac)和R(Cho)与细胞分化无关。结论肺腺癌患者SUV与R(Lac)、R(Cho)无明显相关性。与体外MRS测定的R(Lac)和R(Cho)相比，(18)F-FDG摄取能更好地反映肺腺癌患者的预后。
UNLABELLED It has been reported that (18)F-FDG uptake, lactate concentration, and choline concentration are good indicators of malignant grade in several different kinds of tumors. In this study, we investigated the correlation between (18)F-FDG uptake in (18)F-FDG PET imaging, lactate concentration and choline concentration measured by in vitro (1)H magnetic resonance spectroscopy (MRS), and survival probabilities in human lung adenocarcinoma. METHODS Nineteen patients with lung adenocarcinoma underwent (18)F-FDG PET before surgery. The (1)H MRS spectra were obtained in vitro from methanol-chloroform-water extracts of lung adenocarcinomas and normal lungs. The ratios of the lactate (R(lac)) or choline (R(cho)) concentration of lung adenocarcinoma to normal lung from the same patient were correlated with the mean standardized uptake value (SUV). The Kaplan-Meier life table method was used to analyze the relationship between (18)F-FDG uptake, R(lac), R(cho), and patient survival probabilities. RESULTS There was no significant correlation between mean SUV and R(lac) or R(cho) in patients with lung adenocarcinoma. An SUV > 5 means poorer survival probabilities in patients with lung adenocarcinoma (P = 0.004). A higher R(lac) probably indicates a trend for patients with lung adenocarcinoma to have poorer survival probabilities; however, R(cho) is not an indicator of survival probability. (18)F-FDG uptake significantly correlated with cell differentiation (P = 0.007), whereas R(lac) and R(cho) had no correlation with it. CONCLUSION No significant correlation was found between SUV and R(lac) or R(cho) in patients with lung adenocarcinoma. Compared with R(lac) and R(cho) measured by in vitro MRS, (18)F-FDG uptake is a better indicator of prognosis in patients with lung adenocarcinoma.