Biological Sciences: Adrenal Tyrosine Hydroxylase and Dopamine β-Hydroxylase in Spontaneously Hypertensive Rats
Biological Sciences: Adrenal Tyrosine Hydroxylase and Dopamine β-Hydroxylase in Spontaneously Hypertensive Rats
复制标题
生物科学：自发性高血压大鼠的肾上腺酪氨酸羟化酶和多巴胺 β-羟化酶
作者：
I. Nagatsu;T. Nagatsu;K. Mizutani;H. Umezawa;M. Matsuzaki;T. Takeuchi
自发性高血压（SH）大鼠，一种Wistar品系1，对于筛选抑制儿茶酚胺激素生物合成的抗高血压药物非常有用。本文报道酪氨酸羟化酶和多巴胺β-羟化酶抑制剂对SH大鼠有明显的消肿作用，并能增加肾上腺中酪氨酸羟化酶和多巴胺β-羟化酶的活性。
SPONTANEOUSLY hypertensive (SH) rats, a Wistar strain1, are extremely useful for screening antihypertensive agents which inhibit the biosynthesis of catecholamine hormones. We describe here a pronounced hypotensive action of the inhibitors of tyrosine hydroxylase and dopamine β-hydroxylase on SH rats and an increase in tyrosine hydroxylase and dopamine β-hydroxylase activities in the adrenal glands.