Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment.
Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment.
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DOI：
10.1093/rheumatology/kev347
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Tak PP
中科院分区：
文献类型：
--
作者：
Gerlag DM;Norris JM;Tak PP
对 RA 早期阶段的研究的最新进展为从健康状态到患病状态的过程提供了更多的见解。这些见解为 RA 预防策略的制定开辟了道路，这代表了从治疗到预防的重大范式转变，将对患者和社会产生重大影响。如果能够预防临床体征和症状、残疾、生活质量受损以及长期免疫抑制治疗的需要，这将是向前迈出的一大步。 RA 可以被视为一种典型的自身免疫性疾病，关于 RA 临床前疾病状态的发现可能会促进预防其他免疫介导的炎症性疾病（如 1 型糖尿病、SLE 和多发性硬化症）的研究。本综述重点关注当前对 RA 发展因素的了解，并讨论了干预的机会。
Recent advances in research into the earliest phases of RA have provided additional insights into the processes leading from the healthy to the diseased state. These insights have opened the way for the development of preventive strategies for RA, which represents a significant paradigm shift from treatment to prevention and will have major implications for patients as well as society. It would be a huge step forward if clinical signs and symptoms, disability, impaired quality of life and the need for chronic immunosuppressive treatment could be prevented. RA can be seen as a prototypic autoimmune disease, and discoveries about the preclinical diseased state for RA could potentially facilitate research into prevention of other immune-mediated inflammatory diseases such as type 1 diabetes, SLE and multiple sclerosis. This review focuses on the current knowledge of factors contributing to the development of RA and discusses the opportunities for intervention.