Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels
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DOI：
10.1016/j.heares.2004.11.023
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发表时间：
2005-08-01
期刊：
影响因子：
2.8
通讯作者：
Yang, B
中科院分区：
文献类型：
--
作者：
Kaczmarek, LK;Bhattacharjee, A;Yang, B
中枢听觉通路神经元的放电模式编码声音刺激的特定特征，如频率、强度和空间定位。适当模式的产生在很大程度上取决于这些神经元中电压依赖性钾通道的性质。计算声源方向的哺乳动物听觉通路位于脑干中，并且包括从前腹侧耳蜗核（AVCN）中的丛状细胞到斜方体内侧核（MNTB）的主要神经元的连接。为了保持声音定位所需的动作电位定时的保真度，这些神经元表达几种类型的钾通道，包括电压依赖性通道的Kv3和Kv1家族以及Slick和Slack钠依赖性通道。这些通道决定动作电位的模式和重复刺激期间释放的神经递质的量。由这些通道之一Kv3.1b通道携带的电流的幅度在短期内由蛋白质磷酸化调节，并且在长期内由基因表达的变化调节，使得神经元的内在兴奋性不断地由周围听觉环境调节。(c)2005 Elsevier B.V.保留所有权利。
The firing patterns of neurons in central auditory pathways encode specific features of sound stimuli, such as frequency, intensity and localization in space. The generation of the appropriate pattern depends, to a major extent, on the properties of the voltage-dependent potassium channels in these neurons. The mammalian auditory pathways that compute the direction of a sound source are located in the brainstem and include the connection from bushy cells in the anteroventral cochlear nucleus (AVCN) to the principal neurons of the medial nucleus of the trapezoid body (MNTB). To preserve the fidelity of timing of action potentials that is required for Sound localization, these neurons express several types of potassium channels, including the Kv3 and Kv1 families of voltage-dependent channels and the Slick and Slack sodium-dependent channels. These channels determine the pattern of action potentials and the amount of neurotransmitter released during repeated stimulation. The amplitude of currents carried by one of these channels, the Kv3.1b channel, is regulated in the short term by protein phosphorylation, and in the long term, by changes in gene expression, such that the intrinsic excitability of the neurons is constantly being regulated by the ambient auditory environment. (c) 2005 Elsevier B.V. All rights reserved.