Building unconventional G protein-coupled receptors, one block at a time.

Building unconventional G protein-coupled receptors, one block at a time.
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DOI:
10.1016/j.tips.2021.04.005
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发表时间:
2021-07
影响因子:
13.8
通讯作者:
Mullick M
Mullick M
中科院分区:
医学1区
文献类型:
--
作者:
Ghosh P;Mullick M

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通过7-跨膜G蛋白偶联受体(GPCR)的典型激活异源三聚体G蛋白的结构,功能和动力学已被详细说明。然而,在过去十年中,新兴的研究已经开始揭示相同的G蛋白如何也可以通过非常规GPCR的不同受体家族来访问和调节。我们能否了解细胞如何组装这些非典型G蛋白偶联受体的共同主题和变化?
The structure, function, and dynamics of canonical activation heterotrimeric G proteins by the 7-transmembrane G-protein coupled receptors (GPCRs) has been illustrated in detail. However, emerging studies during the last decade have started to shed light onto how the same G-proteins may be accessed and modulated also by a diverse family of receptors that are not conventional GPCRs. Can we learn about common themes and variations in how cells assemble these atypical G protein-coupled receptors?
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