Building unconventional G protein-coupled receptors, one block at a time.
Building unconventional G protein-coupled receptors, one block at a time.
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DOI:
10.1016/j.tips.2021.04.005
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发表时间:
2021-07
影响因子:
13.8
通讯作者:
Mullick M
中科院分区:
文献类型:
--
作者:
Ghosh P;Mullick M
The structure, function, and dynamics of canonical activation heterotrimeric G proteins by the 7-transmembrane G-protein coupled receptors (GPCRs) has been illustrated in detail. However, emerging studies during the last decade have started to shed light onto how the same G-proteins may be accessed and modulated also by a diverse family of receptors that are not conventional GPCRs. Can we learn about common themes and variations in how cells assemble these atypical G protein-coupled receptors?
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