Developmental Tuning in a Spinal Nociceptive System: Effects of Neonatal Spinalization
Developmental Tuning in a Spinal Nociceptive System: Effects of Neonatal Spinalization
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脊柱伤害感受系统的发育调节：新生儿脊柱化的影响
DOI：
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发表时间：
1999
影响因子：
5.3
通讯作者：
J. Schouenborg
中科院分区：
文献类型：
--
作者：
A. Levinsson;Xiao;H. Holmberg;J. Schouenborg
最近的研究表明，伤害性退缩反射系统的模块化组织。每个模块都有一个特征性的感受野，与其效应肌肉引起的撤回运动密切匹配。在大鼠中，每个模块的感觉输入强度在产后第一周内得到调整，即，错误的脊柱连接被抑制，并且适当的连接被加强。为了澄清这种调节是否取决于脊髓上结构，研究了新生儿脊髓完全切断对产后撤退反射调节的影响。在去大脑、未麻醉和清醒的大鼠上，分别观察了后肢单块肌肉的伤害感受野和复合缩足反射。采用夜间热CO2激光刺激诱发反射反应。新生儿脊髓横断导致成年大鼠的反射组织中断，类似于以前在新生大鼠中发现的。单个后肢肌肉感受野的敏感性分布与效应肌的回缩动作不匹配。同样，复合伤害反应运动，如记录在清醒的大鼠，往往导致错误的运动对刺激。它的结论是，撤回反射不成为功能适应在大鼠出生时脊髓。这些发现表明脊髓上系统在脊髓伤害性系统的出生后调谐中起着关键作用。
Recent studies indicate a modular organization of the nociceptive withdrawal reflex system. Each module has a characteristic receptive field, closely matching the withdrawal movement caused by its effector muscle. In the rat, the strength of the sensory input to each module is tuned during the first postnatal weeks, i.e., erroneous spinal connections are depressed, and adequate connections are strengthened. To clarify if this tuning is dependent on supraspinal structures, the effect of a complete neonatal spinal cord transection on the postnatal tuning of withdrawal reflexes was studied. The nociceptive receptive fields of single hindlimb muscles and compound withdrawal reflexes were examined in decerebrate unanesthetized and awake rats, respectively. Noxious thermal CO2 laser stimulation was used to evoke reflex responses. Neonatal spinal cord transection resulted in a disrupted reflex organization in the adult rat, resembling that previously found in neonatal rats. The receptive fields of single hindlimb muscles exhibited abnormal distribution of sensitivity not matching the withdrawal action of the effector muscles. Likewise, the composite nocifensive movements, as documented in the awake rat, often resulted in erroneous movements toward the stimulus. It is concluded that withdrawal reflexes do not become functionally adapted in rats spinalized at birth. These findings suggest a critical role for supraspinal systems in the postnatal tuning of spinal nociceptive systems.
胚胎脊髓移植增强了脊髓化新生大鼠的运动能力。
影响因子：
--
作者：
Tessler,A;Fischer,I;Giszter,S;Himes,BT;Miya,D;Mori,F;Murray,M
通讯作者：
Murray,M
新生儿牵张反射的发展：相互激发和反射照射。
影响因子：
4.6
作者：
Myklebust,BM;Gottlieb,GL
通讯作者：
Gottlieb,GL