Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens
Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens
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DOI：
10.1038/nn1713
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发表时间：
2006-07-01
影响因子：
25
通讯作者：
Bonci, Antonello
中科院分区：
文献类型：
--
作者：
Martin, Miquel;T Chen, Billy;Bonci, Antonello
伏隔核的核壳在药物依赖行为中起着关键的、不同的作用。本研究表明，在戒断1天后，可操作性可卡因自我给药抑制两种结构的长期抑郁（LTD）。然而，戒断21 d后，可卡因自我给药大鼠伏隔核的LTD完全消失，这表明自愿可卡因自我给药诱导了核心的长期神经适应，这可能是寻求药物行为和复发的基础。
The core and shell of the nucleus accumbens have critical, differential roles in drug-dependent behaviors. Here we show that operant cocaine self-administration inhibits long-term depression ( LTD) in both structures after 1 d of abstinence. However, after 21 d of abstinence, LTD was abolished exclusively in the nucleus accumbens core of cocaine self-administering rats, suggesting that voluntary cocaine self-administration induced long- lasting neuroadaptations in the core that could underlie drug-seeking behavior and relapse.