The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma
The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma
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DOI：
10.1007/s00423-009-0574-9
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发表时间：
2010-08-01
影响因子：
2.3
通讯作者：
Latteri, Mario Adelfio
中科院分区：
文献类型：
--
作者：
Cipolla, Calogero;Cabibi, Daniela;Latteri, Mario Adelfio
在乳腺癌分期中，术中前哨淋巴结（SLN）评估的必要性尚未充分确定。本研究探讨术中冰冻切片（FS）评估SLN对避免SLN阳性患者随后进行腋窝淋巴结清扫术（ALND）的影响。对364例接受SLN活检的乳腺癌患者进行术中FS评估SLN的回顾性分析。FS检查SLN的敏感性和准确性分别为76.4%和94.2%。较大肿瘤的敏感性显着更高 (p < 0.01)。 FS 与组织学类型之间未发现显着相关性。 83.9% 的 SLN 阳性患者避免了第二次干预。术中 FS 检查 SLN 是乳腺癌患者腋窝淋巴结状态的有用预测指标。大多数 SLN 阳性患者允许在一阶段手术中立即进行 ALND。
In breast cancer staging, the need for intraoperative sentinel lymph node (SLN) evaluation has still not been adequately established. This study investigates the impact of intraoperative frozen section (FS) evaluation of SLN to avoid subsequent axillary lymph node dissection (ALND) in patients with positive SLN.A retrospective review of 364 breast cancer patients undergoing SLN biopsy with intraoperative FS evaluation of SLN was performed.Sensitivity and accuracy of FS examination of SLN were 76.4% and 94.2%, respectively. The sensitivity was significantly higher in larger tumors (p < 0.01). No significant correlation was found between FS and histologic type. A second intervention was avoided in 83.9% of the patients with positive SLN.Intraoperative FS examination of the SLN is a useful predictor of axillary lymph node status in breast cancer patients. The majority of SLN-positive patients allows for immediate ALND in a one-stage surgical procedure.