Characterization of Pseudomonas aeruginosa isolates:: Occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999
Characterization of Pseudomonas aeruginosa isolates:: Occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999
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DOI：
10.1086/320186
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发表时间：
2001-05-15
影响因子：
11.8
通讯作者：
Ramphal, R
中科院分区：
文献类型：
--
作者：
Gales, AC;Jones, RN;Ramphal, R
1997~1999年间，哨点计划共分离出70067株铜绿假单胞菌(6631株)，按地理区域和人体感染部位进行分析。呼吸道是铜绿假单胞菌最常见的来源。铜绿假单胞菌分离率在研究期间有所增加。欧洲是唯一一个β-内酰胺类和氨基糖苷类药物敏感率显著下降的地区。加拿大分离株对亚胺培南和拉丁美洲分离株对美罗培南的敏感率降低。共观察到218株多重耐药铜绿假单胞菌(MDR-PSA；对哌拉西林、头孢他啶、亚胺培南和庆大霉素耐药)；MDR-PSA发生率(占所有菌株的百分比)从8.2%(拉丁美洲)到0.9%(加拿大)不等。50%的MDR-PSA菌株无抗菌药物抑制。对选定的、普遍耐药的菌株进行了分子鉴定。在欧洲、拉丁美洲和美国发现了显示独特核群的分离株，但在几个医学中心记录了克隆性传播。
During 1997-1999, a total of 70,067 isolates (6631 Pseudomonas aeruginosa isolates) were analyzed in the SENTRY program by geographic region and body site of infection. The respiratory tract was the most common source of P. aeruginosa. P. aeruginosa isolation rates increased during the study interval. Europe was the only region to show a significant decline in beta -lactam and aminoglycoside susceptibility rates. There was a reduction in the rates of susceptibility of Canadian isolates to imipenem and of Latin American isolates to meropenem. A total of 218 multidrug-resistant P. aeruginosa isolates (MDR-PSA; resistant to piperacillin, ceftazidime, imipenem, and gentamicin) were observed; MDR-PSA occurrence rates (percentages of all isolates) ranged from 8.2% (Latin America) to 0.9% (Canada). No antimicrobial inhibited > 50% of MDR-PSA strains. Molecular characterization of selected, generally resistant strains was performed. Isolates showing unique ribogroups were found in Europe, Latin America, and the United States, but clonal spread was documented in several medical centers.