Structural abnormalities detected by knee magnetic resonance imaging are common in middle-aged subjects with and without risk factors for osteoarthritis
Structural abnormalities detected by knee magnetic resonance imaging are common in middle-aged subjects with and without risk factors for osteoarthritis
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DOI：
10.1080/17453674.2018.1495164
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发表时间：
2018-01-01
影响因子：
3.7
通讯作者：
Englund, Martin
中科院分区：
文献类型：
--
作者：
Kumm, Jaanika;Turkiewicz, Aleksandra;Englund, Martin
背景和目的-关于无明显骨关节炎（OA）的膝关节结构改变的数据很少。我们评估了在中年受试者中通过磁共振成像（MRI）提示膝关节OA的患病率，这些受试者无放射学OA，有或无OA风险factors.Patients和Methods - 340例来自骨关节炎倡议的受试者，年龄45-55岁（51%女性），双膝Kelling-Lawrence 0级，有3 T膝关节MR图像。294例受试者有危险因素，46例无危险因素。结果：96%（283/294）的有危险因素的受试者和87%（40/46）的无危险因素的受试者至少发现1个MR检测特征。在有风险因素的受试者中，软骨损伤（82%）、骨髓病变（60%）、骨赘（45%）、骨小体挤出（32%）和滑膜炎-积液（29%）是最常见的结果，而在无风险因素的受试者中，软骨损伤（67%）、骨赘（46%）、骨小体挤出（37%）和骨髓病变（35%）最常见。有OA风险因素的受试者中任何异常的患病率均高于无OA风险因素的受试者（经年龄和性别校正的患病率比为1.3 [95% CI 1.1-1.6]），软骨下囊肿和骨髓病变的患病率也是如此。MR检测到的结构变化在髌股关节中更为频繁。解释-我们的研究结果强调了区分早期膝关节OA的病理特征与被认为是“正常衰老”的一部分的巨大挑战。“骨髓病变在具有多种OA风险因素的受试者中更常见。
Background and purpose - Few data are available regarding structural changes present in knees without radiographically evident osteoarthritis (OA). We evaluated the prevalence of findings suggestive of knee OA by magnetic resonance imaging (MRI) in middle-aged subjects without radiographic OA with or without OA risk factors.Patients and methods - 340 subjects from the Osteoarthritis Initiative, aged 45-55 years (51% women) with Kellgren-Lawrence grade 0 in both knees, who had 3T knee MR images were eligible. 294 subjects had risk factors and 46 were without risk factors. MR images were assessed using the MOAKS scoring system.Results - At least 1 MR-detected feature was found in 96% (283/294) of subjects with risk factors and in 87% (40/46) of those without. Cartilage damage (82%), bone marrow lesions (60%), osteophytes (45%), meniscal body extrusion (32%), and synovitis-effusion (29%) were the most common findings in subjects with risk factors, while cartilage damage (67%), osteophytes (46%), meniscal body extrusion (37%), and bone marrow lesions (35%) were most common in subjects without. The prevalence of any abnormality was higher in subjects with OA risk factors than in subjects without (prevalence ratio adjusted for age and sex 1.3 [95% CI 1.1-1.6]), so was prevalence of subchondral cysts and bone marrow lesions. MR-detected structural changes were more frequent in patellofemoral joints.Interpretation - Our findings highlight the great challenge in distinguishing pathological features of early knee OA from what could be considered part of "normal ageing." Bone marrow lesions were more frequently found in subjects with multiple OA risk factors.