Activation of the Rostral Intralaminar Thalamus Drives Reinforcement through Striatal Dopamine Release
Activation of the Rostral Intralaminar Thalamus Drives Reinforcement through Striatal Dopamine Release
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DOI：
10.1016/j.celrep.2019.01.044
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发表时间：
2019-02-05
期刊：
影响因子：
8.8
通讯作者：
Mathur, Brian N.
中科院分区：
文献类型：
--
作者：
Cover, Kara K.;Gyawali, Utsav;Mathur, Brian N.
丘脑吻侧板内核（rILN）的谷氨酸能投射支配背侧纹状体（DS），并参与多巴胺（DA）依赖的药物寻求的潜伏期。然而，rILN信号调节奖赏寻求和纹状体DA释放的机制尚不清楚。我们发现，激活rILN输入DS驱动胆碱能中间神经元的爆发式放电行为和DA D2受体依赖性后爆发暂停胆碱能中间神经元放电。在体内，该途径的光遗传激活以DA D1受体依赖性方式驱动强化，并且rILN的化学发生抑制降低多巴胺能黑质纹状体末端活性，如通过纤维光度法测量的。总而言之，这些数据提供的证据表明，rILN激活纹状体胆碱能中间神经元，以提高追求奖励通过当地纹状体DA释放，并引入了额外的复杂性水平，我们的理解纹状体DA信号。
Glutamatergic projections of the thalamic rostral intralaminar nuclei of the thalamus (rILN) innervate the dorsal striatum (DS) and are implicated in dopamine (DA)-dependent incubation of drug seeking. However, the mechanism by which rILN signaling modulates reward seeking and striatal DA release is unknown. We find that activation of rILN inputs to the DS drives cholinergic interneuron burst-firing behavior and DA D2 receptor-dependent post-burst pauses in cholinergic interneuron firing. In vivo, optogenetic activation of this pathway drives reinforcement in a DA D1 receptor-dependent manner, and chemogenetic suppression of the rILN reduces dopaminergic nigrostriatal terminal activity as measured by fiber photometry. Altogether, these data provide evidence that the rILN activates striatal cholinergic interneurons to enhance the pursuit of reward through local striatal DA release and introduce an additional level of complexity in our understanding of striatal DA signaling.