Nodal metastases - Predictive factors
Nodal metastases - Predictive factors
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DOI：
10.1016/s0030-6665(05)70076-1
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发表时间：
1998-08-01
影响因子：
1.7
通讯作者：
Medina, JE
中科院分区：
文献类型：
--
作者：
Kowalski, LP;Medina, JE
上呼吸道和消化道鳞状细胞癌颈部转移风险高，降低了局部控制和生存的概率。我们分析文献和我们自己的经验来回顾可能发生转移的危险因素。最重要的危险因素是：肿瘤部位和大小、组织学分化程度、肿瘤厚度（口腔癌舌部和底部）、血管栓塞和神经周围浸润。在过去的10年里，人们研究了一系列的生物标志物，但没有一种被证明具有足够的临床应用价值。基于多因素分析，建议高危患者择期进行颈部治疗。
Squamous cell carcinoma of the upper respiratory and digestive tract has a high risk for neck metastasis, which reduces the probability of regional control and survival. We analyzed the literature and our own experience to review the possible risk factors for the occurrence of metastasis. The most significant risk factors were: tumor site and size, grade of histologic differentiation, tumor thickness (tongue and floor of mouth carcinoma), vascular embolization, and perineural infiltration. A series of biomarkers has been studied over the last 10 years, but no one has proved to be significant enough for clinical use. Based on several multivariate analysis, it is recommended elective treatment of the neck for high-risk patients.