Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes
Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes
复制标题
DOI：
10.1007/s007020050087
复制
发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Mizuno, Y
中科院分区：
文献类型：
--
作者：
Morikawa, N;Naoi, M;Mizuno, Y
本文报道了四氢异喹啉衍生物对线粒体呼吸和电子传递复合物的影响。通常，这些化合物是NADH连接的线粒体状态3呼吸和复合物I的有效抑制剂。在C1位存在苯基或N-甲基化异醌氧化成N-甲基异喹啉离子增强了抑制线粒体呼吸和复合物I的效力。这些化合物中的许多已经在人类大脑中被鉴定出来。鉴于线粒体和氧化应激假说，我们的研究结果表明参与这些神经毒素作为帕金森病线粒体功能衰竭的潜在原因。
We report effect of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes. Generally these compounds were potent inhibitors of NADH-linked mitochondrial state 3 respiration and complex I. Presence of a phenyl group at the C1 position or oxidation of N-methylated isoquinones into N-methylisoquinolinium ion augmented the potency to inhibit mitochondrial respiration and complex I. Many of these compounds have been identified in human brains. In view of the mitochondrial and oxidative stress hypothesis, our results suggest involvement of these neurotoxins as potential causes of mitochondrial failure in Parkinson's disease.