NEUROLOGICAL DISORDERS IN AIDS AND HIV DISEASE IN THE NORTHERN ZONE OF TANZANIA
NEUROLOGICAL DISORDERS IN AIDS AND HIV DISEASE IN THE NORTHERN ZONE OF TANZANIA
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DOI：
10.1097/00002030-198905000-00007
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发表时间：
1989-05-01
期刊：
影响因子：
3.8
通讯作者：
MISSALEK, WR
中科院分区：
文献类型：
--
作者：
HOWLETT, WP;NKYA, WM;MISSALEK, WR
这项研究介绍了坦桑尼亚北部乞力马扎罗基督教医疗中心200名艾滋病患者的主要临床表现，并对其中135名患者和53名对照组进行了详细的神经学检查。结果显示，200例中有21例(10.5%)有明显的局灶性神经功能障碍，包括脑神经麻痹、偏瘫和截瘫。在135名患者中，97名(72%)有较不明显的神经功能障碍，而对照组为36%(P<；0.005)。最常见的是艾滋病痴呆综合征(54%)、视网膜病变(23%)、反射障碍(21%)、锥体束体征(19%)和震颤和协调不良(19%)。额叶松弛征(FLOR)在135例患者中有103例(76%)，而对照组为36%(P<；0.005)。晚期和晚期艾滋病患者比早期艾滋病患者更有可能出现神经障碍。
This study presents the main clinical findings on 200 AIDS patients at Kilimanjaro Christian Medical Centre in the northern zone of Tanzania, with detailed neurological findings on 135 out of 200 cases and 53 controls. Results show that 21 out of 200 (10.5%) had an obvious focal neurological disorder, including cranial nerve palsies, hemiparesis and paraparesis. Ninety-seven out of 135 (72%) had less obviously detectable neurological disorders, versus 36% of controls (P< 0.005). Most frequent were AIDS dementia complex (54%), retinopathy (23%), areflexia (21%), pyramidal tract signs (19%) and tremor and incoordination (19%). Frontal lobe release signs (FLRS) were found in 103 out of 135 (76%) patients, versus 36% of controls (P< 0.005). Advanced and terminal AIDS cases were more likely to have neurological disorders than early AIDS patients.