Sequence and phylogenetic position of a class II aldolase gene in the amitochondriate protist, Giardia lamblia
Sequence and phylogenetic position of a class II aldolase gene in the amitochondriate protist, Giardia lamblia
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DOI：
10.1016/s0378-1119(98)00499-5
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发表时间：
1998-11-19
期刊：
影响因子：
3.5
通讯作者：
Müller, M
中科院分区：
文献类型：
--
作者：
Henze, K;Morrison, HG;Müller, M
克隆了蓝氏贾第鞭毛虫Glfba基因并进行了序列测定。该基因编码324个残基长的推定II类果糖-1，6-二磷酸醛缩酶。缺口的位置和系统发育分析与最大似然法和最大简约法显示的序列是最密切相关的迄今尚未表征的醛缩酶的幽门螺杆菌和Aquifex aeolicus和组，包括卡尔文循环的光合蛋白细菌和蓝藻的醛缩酶。结合已知的I类和II类醛缩酶的分类和功能分布，结果表明G。Lamblia酶在其进化历史上不同于迄今为止研究的所有真核果糖-1，6-二磷酸醛缩酶。(C)1998年由Elsevier Science B. V.出版，版权所有。
A Giardia lamblia gene, Glfba, was cloned and sequenced. This gene codes for a 324-residue-long putative class II fructose-1,6-bisphosphate aldolase. The positions of gaps and phylogenetic analysis with maximum likelihood and maximum parsimony methods showed the sequence to be most closely related to the as-yet uncharacterized aldolases of Helicobacter pylori and Aquifex aeolicus and to the group that comprises the Calvin-cycle aldolases of photosynthetic proteobacteria and cyanobacteria. In combination with the known taxonomic and functional distribution of class I and II aldolases, the results indicate that the G. lamblia enzyme is distinct in its evolutionary history from all eukaryotic fructose-1,6-bisphosphate aldolases studied so far. (C) 1998 Published by Elsevier Science B.V. All rights reserved.